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Target Report Card

Target Name and Classification

Target ID CHEMBL5888
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase 14
Synonyms HsNIK | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | NF-kappa-beta-inducing kinase | NIK | Serine/threonine-protein kinase NIK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase unique family

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 14 SINGLE PROTEIN Q99558

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000006062
Ensembl ENSG00000006062
GO Cellular Component GO:0001650 (fibrillar center)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004704 (NF-kappaB-inducing kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0006468 (protein phosphorylation)
GO:0006955 (immune response)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0031295 (T cell costimulation)
GO:0032147 (activation of protein kinase activity)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0051607 (defense response to virus)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia MAP3K14

Target Cross References - Protein

canSAR Q99558
Human Protein Atlas ENSG00000006062
IntAct Q99558
Guide to Pharmacology 2074
Open Targets ENSG00000006062
PharmGKB PA30597
Pharos Q99558 (Tchem)
Reactome R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-5607761 (Dectin-1 mediated noncanonical NF-kB signaling.)
R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-5676590 (NIK-->noncanonical NF-kB signaling.)
R-HSA-5676594 (TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.)
UniProt A8K2D8 D3DX67 Q8IYN1 Q99558

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017425 (MAPKKK14.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4DN5 4G3D 4IDT 4IDV
CREDO 4DN5 4G3D 4IDT 4IDV
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