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Target Report Card

Target Name and Classification

Target ID CHEMBL5873
Preferred Name Solute carrier family 2, facilitated glucose transporter member 2
Synonyms GLUT-2 | GLUT2 | Glucose transporter type 2, liver | SLC2A2 | Solute carrier family 2, facilitated glucose transporter member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc02 family of hexose and sugar alcohol transporters

Target Components

Component Description Relationship Accession
Solute carrier family 2, facilitated glucose transporter member 2 SINGLE PROTEIN P11168

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163581
Ensembl ENSG00000163581
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005903 (brush border)
GO:0005911 (cell-cell junction)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0031526 (brush border membrane)
GO Molecular Function GO:0005158 (insulin receptor binding)
GO:0005215 (transporter activity)
GO:0005355 (glucose transmembrane transporter activity)
GO:0015149 (hexose transmembrane transporter activity)
GO:0022857 (transmembrane transporter activity)
GO:0022891 (substrate-specific transmembrane transporter activity)
GO:0033300 (dehydroascorbic acid transporter activity)
GO:0055056 (D-glucose transmembrane transporter activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006810 (transport)
GO:0008643 (carbohydrate transport)
GO:0008645 (hexose transport)
GO:0009749 (response to glucose)
GO:0009758 (carbohydrate utilization)
GO:0015755 (fructose transport)
GO:0015758 (glucose transport)
GO:0043434 (response to peptide hormone)
GO:0050796 (regulation of insulin secretion)
GO:0055085 (transmembrane transport)
GO:0070837 (dehydroascorbic acid transport)
GO:1904659 (glucose transmembrane transport)

Target Cross References - Protein

canSAR P11168
CGD Fanconi-Bickel syndrome; Glycogen storage disease XI; Neonatal diabetes mellitus
Human Protein Atlas ENSG00000163581
IntAct P11168
Open Targets ENSG00000163581
PharmGKB PA35876
Reactome R-HSA-189200 (Hexose transport.)
R-HSA-210745 (Regulation of gene expression in beta cells.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-428790 (Facilitative Na+-independent glucose transporters.)
R-HSA-70153 (Glucose transport.)
UniProt A8K481 B2R936 B7Z547 F8W8V8 P11168 Q9UCW9

Target Cross References - Domain

InterPro IPR002440 (Glc_transpt_2.)
IPR003663 (Sugar/inositol_transpt.)
IPR005828 (MFS_sugar_transport-like.)
IPR005829 (Sugar_transporter_CS.)
IPR020846 (MFS_dom.)
Pfam PF00083 (Sugar_tr)