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Target Report Card

Target Name and Classification

Target ID CHEMBL5859
Preferred Name RAC-alpha serine/threonine-protein kinase
Synonyms AKT1 kinase | Akt | Akt1 | PKB alpha | PKB | Protein kinase B alpha | Protein kinase B | Proto-oncogene c-Akt | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase | Rac | Thymoma viral proto-oncogene
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase akt family

Target Components

Component Description Relationship Accession
RAC-alpha serine/threonine-protein kinase SINGLE PROTEIN P31750

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0031982 (vesicle)
GO:0036064 (ciliary basal body)
GO:0043234 (protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005547 (phosphatidylinositol-3,4,5-trisphosphate binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0030235 (nitric-oxide synthase regulator activity)
GO:0032794 (GTPase activating protein binding)
GO:0042802 (identical protein binding)
GO:0043325 (phosphatidylinositol-3,4-bisphosphate binding)
GO:0051721 (protein phosphatase 2A binding)
GO:0071889 (14-3-3 protein binding)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0001649 (osteoblast differentiation)
GO:0001893 (maternal placenta development)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0005975 (carbohydrate metabolic process)
GO:0005977 (glycogen metabolic process)
GO:0005978 (glycogen biosynthetic process)
GO:0005979 (regulation of glycogen biosynthetic process)
GO:0006006 (glucose metabolic process)
GO:0006412 (translation)
GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006810 (transport)
GO:0006915 (apoptotic process)
GO:0006924 (activation-induced cell death of T cells)
GO:0006954 (inflammatory response)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006979 (response to oxidative stress)
GO:0007010 (cytoskeleton organization)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0007281 (germ cell development)
GO:0007399 (nervous system development)
GO:0007568 (aging)
GO:0008286 (insulin receptor signaling pathway)
GO:0008637 (apoptotic mitochondrial changes)
GO:0008643 (carbohydrate transport)
GO:0009725 (response to hormone)
GO:0010033 (response to organic substance)
GO:0010507 (negative regulation of autophagy)
GO:0010629 (negative regulation of gene expression)
GO:0010748 (negative regulation of plasma membrane long-chain fatty acid transport)
GO:0010763 (positive regulation of fibroblast migration)
GO:0010765 (positive regulation of sodium ion transport)
GO:0010907 (positive regulation of glucose metabolic process)
GO:0010951 (negative regulation of endopeptidase activity)
GO:0010975 (regulation of neuron projection development)
GO:0015758 (glucose transport)
GO:0016310 (phosphorylation)
GO:0016567 (protein ubiquitination)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021510 (spinal cord development)
GO:0030030 (cell projection organization)
GO:0030163 (protein catabolic process)
GO:0030212 (hyaluronan metabolic process)
GO:0030307 (positive regulation of cell growth)
GO:0030334 (regulation of cell migration)
GO:0031641 (regulation of myelination)
GO:0031659 (positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0031999 (negative regulation of fatty acid beta-oxidation)
GO:0032079 (positive regulation of endodeoxyribonuclease activity)
GO:0032094 (response to food)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032287 (peripheral nervous system myelin maintenance)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032869 (cellular response to insulin stimulus)
GO:0032880 (regulation of protein localization)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034405 (response to fluid shear stress)
GO:0035556 (intracellular signal transduction)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0036294 (cellular response to decreased oxygen levels)
GO:0042593 (glucose homeostasis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043491 (protein kinase B signaling)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045725 (positive regulation of glycogen biosynthetic process)
GO:0045792 (negative regulation of cell size)
GO:0045861 (negative regulation of proteolysis)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046326 (positive regulation of glucose import)
GO:0046329 (negative regulation of JNK cascade)
GO:0046889 (positive regulation of lipid biosynthetic process)
GO:0048009 (insulin-like growth factor receptor signaling pathway)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051146 (striated muscle cell differentiation)
GO:0060416 (response to growth hormone)
GO:0060709 (glycogen cell differentiation involved in embryonic placenta development)
GO:0060716 (labyrinthine layer blood vessel development)
GO:0061024 (membrane organization)
GO:0070141 (response to UV-A)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071364 (cellular response to epidermal growth factor stimulus)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071456 (cellular response to hypoxia)
GO:0072655 (establishment of protein localization to mitochondrion)
GO:0072656 (maintenance of protein location in mitochondrion)
GO:0090004 (positive regulation of establishment of protein localization to plasma membrane)
GO:0090201 (negative regulation of release of cytochrome c from mitochondria)
GO:0097011 (cellular response to granulocyte macrophage colony-stimulating factor stimulus)
GO:0097194 (execution phase of apoptosis)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:1901653 (cellular response to peptide)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:1990418 (response to insulin-like growth factor stimulus)

Target Cross References - Protein

IntAct P31750
Reactome R-MMU-114604 (GPVI-mediated activation cascade.)
R-MMU-1257604 (PIP3 activates AKT signaling.)
R-MMU-1358803 (Downregulation of ERBB2:ERBB3 signaling.)
R-MMU-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-MMU-1474151 (Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.)
R-MMU-165159 (mTOR signalling.)
R-MMU-165160 (PDE3B signalling.)
R-MMU-198323 (AKT phosphorylates targets in the cytosol.)
R-MMU-198693 (AKT phosphorylates targets in the nucleus.)
R-MMU-199418 (Negative regulation of the PI3K/AKT network.)
R-MMU-203615 (eNOS activation.)
R-MMU-211163 (AKT-mediated inactivation of FOXO1A.)
R-MMU-354192 (Integrin alphaIIb beta3 signaling.)
R-MMU-3769402 (Deactivation of the beta-catenin transactivating complex.)
R-MMU-389357 (CD28 dependent PI3K/Akt signaling.)
R-MMU-389513 (CTLA4 inhibitory signaling.)
R-MMU-392451 (G beta:gamma signalling through PI3Kgamma.)
R-MMU-450385 (Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.)
R-MMU-450604 (KSRP (KHSRP) binds and destabilizes mRNA.)
R-MMU-5218920 (VEGFR2 mediated vascular permeability.)
R-MMU-5628897 (TP53 Regulates Metabolic Genes.)
R-MMU-6804757 (Regulation of TP53 Degradation.)
R-MMU-6804758 (Regulation of TP53 Activity through Acetylation.)
R-MMU-6804759 (Regulation of TP53 Activity through Association with Co-factors.)
R-MMU-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-MMU-69202 (Cyclin E associated events during G1/S transition.)
R-MMU-8849469 (PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.)
R-MMU-8876198 (RAB GEFs exchange GTP for GDP on RABs.)
UniProt P31750 Q62274 Q6GSA6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001849 (PH_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00169 (PH)
PF00433 (Pkinase_C)