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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5855
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase Nek1
Synonyms KIAA1901 | NEK1 | Never in mitosis A-related kinase 1 | NimA-related protein kinase 1 | Renal carcinoma antigen NY-REN-55 | Serine/threonine-protein kinase Nek1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase nek family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase Nek1 SINGLE PROTEIN Q96PY6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137601
Ensembl ENSG00000137601
GO Cellular Component GO:0000242 (pericentriolar material)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005856 (cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0071889 (14-3-3 protein binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030030 (cell projection organization)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0032147 (activation of protein kinase activity)
GO:0042769 (DNA damage response, detection of DNA damage)
GO:0042981 (regulation of apoptotic process)
GO:0051301 (cell division)
GO:0060271 (cilium morphogenesis)
Wikipedia NEK1

Target Cross References - Protein

canSAR Q96PY6
CGD Short rib-polydactyly syndrome, type II
Human Protein Atlas ENSG00000137601
IntAct Q96PY6
Guide to Pharmacology 2114
Open Targets ENSG00000137601
PharmGKB PA31545
Pharos Q96PY6 (Tbio)
UniProt G5E9Z3 Q05DG5 Q14CB7 Q5H9T1 Q6PIB8 Q96PY6 Q96SS2 Q9H6P7 Q9Y594

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4APC 4B9D
CREDO 4APC 4B9D
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