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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5854
Target Type SINGLE PROTEIN
Preferred Name Adenylate cyclase type 10
Synonyms ADCY10 | AH-related protein | Adenylate cyclase homolog | Adenylate cyclase type 10 | Germ cell soluble adenylyl cyclase | SAC | Testicular soluble adenylyl cyclase | hsAC | sAC
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 10 SINGLE PROTEIN Q96PN6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143199
Ensembl ENSG00000143199
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005929 (cilium)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0031514 (motile cilium)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0045177 (apical part of cell)
GO:0045178 (basal part of cell)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004016 (adenylate cyclase activity)
GO:0005524 (ATP binding)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0030145 (manganese ion binding)
GO:0046872 (metal ion binding)
GO:0051117 (ATPase binding)
GO:0071890 (bicarbonate binding)
GO Biological Process GO:0003351 (epithelial cilium movement)
GO:0006171 (cAMP biosynthetic process)
GO:0007283 (spermatogenesis)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0035556 (intracellular signal transduction)
GO:0043065 (positive regulation of apoptotic process)
GO:0071241 (cellular response to inorganic substance)
Wikipedia ADCY10

Target Cross References - Protein

Human Protein Atlas ENSG00000143199
Open Targets ENSG00000143199
PharmGKB PA162375618
Reactome R-HSA-5610787 (Hedgehog 'off' state.)
UniProt B4DZF0 F5GWS5 O95558 Q5R329 Q5R330 Q8WXV4 Q96PN6 Q9NNX0

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR011990 (TPR-like_helical_dom.)
IPR016577 (Adenylate_cylcase_typ10.)
IPR027417 (P-loop_NTPase.)
IPR029787 (Nucleotide_cyclase.)
Pfam PF00211 (Guanylate_cyc)

Target Cross References - Structure

PDBe 4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST More...
CREDO 4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST More...
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