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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5847
Target Type SINGLE PROTEIN
Preferred Name Aldo-keto reductase family 1 member C2
Synonyms 3-alpha-HSD3 | AKR1C2 | Aldo-keto reductase family 1 member C2 | Chlordecone reductase homolog HAKRD | DD-2 | DD/BABP | DD2 | DDH2 | Dihydrodiol dehydrogenase 2 | Dihydrodiol dehydrogenase/bile acid-binding protein | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | Type III 3-alpha-hydroxysteroid dehydrogenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldo-keto reductase family 1 member C2 SINGLE PROTEIN P52895

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151632
Ensembl ENSG00000151632
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0016491 (oxidoreductase activity)
GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
GO:0018636 (phenanthrene 9,10-monooxygenase activity)
GO:0031406 (carboxylic acid binding)
GO:0032052 (bile acid binding)
GO:0047086 (ketosteroid monooxygenase activity)
GO:0047115 (trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006693 (prostaglandin metabolic process)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007586 (digestion)
GO:0008202 (steroid metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0030855 (epithelial cell differentiation)
GO:0042448 (progesterone metabolic process)
GO:0044597 (daunorubicin metabolic process)
GO:0044598 (doxorubicin metabolic process)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055114 (oxidation-reduction process)
GO:0071395 (cellular response to jasmonic acid stimulus)
GO:0071799 (cellular response to prostaglandin D stimulus)

Target Cross References - Protein

canSAR P52895
CGD 46,XY sex reversal 8
Human Protein Atlas ENSG00000151632
IntAct P52895
Open Targets ENSG00000151632
PharmGKB PA24678
Reactome R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
UniProt A8K2N9 B4DKR9 P52895 Q14133 Q5SR16 Q7M4N1 Q96A71

Target Cross References - Domain

InterPro IPR001395 (Aldo/ket_red/Kv-b.)
IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 1IHI 1J96 1XJB 2HDJ 2IPJ 4JQ1 4JQ2 4JQ3 4JQ4 4JQA 4JTQ 4JTR 4L1W 4L1X 4XO6 4XO7
CREDO 1IHI 1J96 1XJB 2HDJ 2IPJ 4JQ1 4JQ2 4JQ3 4JQ4 4JQA 4JTQ 4JTR 4L1W 4L1X 4XO6 4XO7
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