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Target Report Card

Target Name and Classification

Target ID CHEMBL5817
Preferred Name Signal transducer and activator of transcription 5B
Synonyms STAT5B | Signal transducer and activator of transcription 5B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Signal transducer and activator of transcription 5B SINGLE PROTEIN P51692

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173757
Ensembl ENSG00000173757
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000979 (RNA polymerase II core promoter sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004713 (protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0019903 (protein phosphatase binding)
GO:0035259 (glucocorticoid receptor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0000255 (allantoin metabolic process)
GO:0001553 (luteinization)
GO:0001666 (response to hypoxia)
GO:0001779 (natural killer cell differentiation)
GO:0001889 (liver development)
GO:0006101 (citrate metabolic process)
GO:0006103 (2-oxoglutarate metabolic process)
GO:0006105 (succinate metabolic process)
GO:0006107 (oxaloacetate metabolic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006549 (isoleucine metabolic process)
GO:0006573 (valine metabolic process)
GO:0006600 (creatine metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006953 (acute-phase response)
GO:0007165 (signal transduction)
GO:0007259 (JAK-STAT cascade)
GO:0007548 (sex differentiation)
GO:0007565 (female pregnancy)
GO:0007595 (lactation)
GO:0008284 (positive regulation of cell proliferation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019218 (regulation of steroid metabolic process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019530 (taurine metabolic process)
GO:0019915 (lipid storage)
GO:0030155 (regulation of cell adhesion)
GO:0030856 (regulation of epithelial cell differentiation)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0032819 (positive regulation of natural killer cell proliferation)
GO:0032825 (positive regulation of natural killer cell differentiation)
GO:0032870 (cellular response to hormone stimulus)
GO:0033077 (T cell differentiation in thymus)
GO:0038161 (prolactin signaling pathway)
GO:0040014 (regulation of multicellular organism growth)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042104 (positive regulation of activated T cell proliferation)
GO:0042448 (progesterone metabolic process)
GO:0043029 (T cell homeostasis)
GO:0043066 (negative regulation of apoptotic process)
GO:0043434 (response to peptide hormone)
GO:0045086 (positive regulation of interleukin-2 biosynthetic process)
GO:0045471 (response to ethanol)
GO:0045579 (positive regulation of B cell differentiation)
GO:0045588 (positive regulation of gamma-delta T cell differentiation)
GO:0045621 (positive regulation of lymphocyte differentiation)
GO:0045647 (negative regulation of erythrocyte differentiation)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045954 (positive regulation of natural killer cell mediated cytotoxicity)
GO:0046449 (creatinine metabolic process)
GO:0046543 (development of secondary female sexual characteristics)
GO:0046544 (development of secondary male sexual characteristics)
GO:0048541 (Peyer's patch development)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050729 (positive regulation of inflammatory response)
GO:0051272 (positive regulation of cellular component movement)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0070669 (response to interleukin-2)
GO:0070670 (response to interleukin-4)
GO:0070672 (response to interleukin-15)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071364 (cellular response to epidermal growth factor stimulus)
GO:0097531 (mast cell migration)
Wikipedia STAT5B

Target Cross References - Protein

canSAR P51692
CGD Growth hormone insensitivity with immunodeficiency
Human Protein Atlas ENSG00000173757
IntAct P51692
Open Targets ENSG00000173757
PharmGKB PA36186
Reactome R-HSA-1170546 (Prolactin receptor signaling.)
R-HSA-1266695 (Interleukin-7 signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1839117 (Signaling by cytosolic FGFR1 fusion mutants.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-2586552 (Signaling by Leptin.)
R-HSA-451927 (Interleukin-2 signaling.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-982772 (Growth hormone receptor signaling.)
UniProt P51692 Q8WWS8

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001217 (STAT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011992 (EF-hand-dom_pair.)
IPR012345 (STAT_TF_DNA-bd_sub.)
IPR013799 (STAT_TF_prot_interaction.)
IPR013800 (STAT_TF_alpha.)
IPR013801 (STAT_TF_DNA-bd.)
IPR015988 (STAT_TF_coiled-coil.)
Pfam PF00017 (SH2)
PF01017 (STAT_alpha)
PF02864 (STAT_bind)
PF02865 (STAT_int)