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Target Report Card

Target Name and Classification

Target ID CHEMBL5776
Preferred Name Mitogen-activated protein kinase kinase kinase 7
Synonyms MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase tak1 subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 7 SINGLE PROTEIN O43318

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135341
Ensembl ENSG00000135341
GO Cellular Component GO:0005634 (nucleus)
GO:0005671 (Ada2/Gcn5/Ada3 transcription activator complex)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0008385 (IkappaB kinase complex)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030971 (receptor tyrosine kinase binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0000187 (activation of MAPK activity)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002726 (positive regulation of T cell cytokine production)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007223 (Wnt signaling pathway, calcium modulating pathway)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007250 (activation of NF-kappaB-inducing kinase activity)
GO:0007252 (I-kappaB phosphorylation)
GO:0007254 (JNK cascade)
GO:0016032 (viral process)
GO:0016239 (positive regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0016579 (protein deubiquitination)
GO:0032743 (positive regulation of interleukin-2 production)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043276 (anoikis)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0043966 (histone H3 acetylation)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051403 (stress-activated MAPK cascade)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0070498 (interleukin-1-mediated signaling pathway)
Wikipedia MAP3K7

Target Cross References - Protein

canSAR O43318
Human Protein Atlas ENSG00000135341
IntAct O43318
Guide to Pharmacology 2082
Open Targets ENSG00000135341
PharmGKB PA30603
Pharos O43318 (Tchem)
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-9014325 (TICAM1,TRAF6-dependent induction of TAK1 complex.)
R-HSA-9020702 (Interleukin-1 signaling.)
R-HSA-937042 (IRAK2 mediated activation of TAK1 complex.)
R-HSA-937072 (TRAF6-mediated induction of TAK1 complex within TLR4 complex.)
R-HSA-975163 (IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.)
UniProt B2RE27 E1P523 O43317 O43318 O43319 Q5TDN2 Q5TDN3 Q5TDT7 Q9NTR3 Q9NZ70

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017421 (MAPKKK7.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N
CREDO 2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N