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Target Report Card

Target Name and Classification

Target ID CHEMBL5774
Preferred Name Monoglyceride lipase
Synonyms MAGL | MGL | Mgll | Monoacylglycerol lipase | Monoglyceride lipase
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Monoglyceride lipase SINGLE PROTEIN O35678

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0019898 (extrinsic component of membrane)
GO:0030424 (axon)
GO:0043196 (varicosity)
GO:0045202 (synapse)
GO Molecular Function GO:0016787 (hydrolase activity)
GO:0042803 (protein homodimerization activity)
GO:0047372 (acylglycerol lipase activity)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0009966 (regulation of signal transduction)
GO:0016042 (lipid catabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0019433 (triglyceride catabolic process)
GO:0030516 (regulation of axon extension)
GO:0046464 (acylglycerol catabolic process)
GO:0050727 (regulation of inflammatory response)
GO:0051930 (regulation of sensory perception of pain)
GO:0060292 (long term synaptic depression)
GO:0097756 (negative regulation of blood vessel diameter)
GO:2000124 (regulation of endocannabinoid signaling pathway)

Target Cross References - Protein

canSAR O35678
IntAct O35678
Reactome R-MMU-1482883 (Acyl chain remodeling of DAG and TAG.)
R-MMU-426048 (Arachidonate production from DAG.)
UniProt O35678 Q3V2R0 Q9D9G8

Target Cross References - Domain

InterPro IPR000073 (AB_hydrolase_1.)
IPR022742 (Hydrolase_4.)
IPR029058 (AB_hydrolase.)
Pfam PF12146 (Hydrolase_4)