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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5754
Target Type SINGLE PROTEIN
Preferred Name MAP/microtubule affinity-regulating kinase 4
Synonyms KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MAP/microtubule affinity-regulating kinase-like 1 | MARK4 | MARKL1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase mark subfamily

Target Components

Component Description Relationship Accession
MAP/microtubule affinity-regulating kinase 4 SINGLE PROTEIN Q96L34

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000007047
Ensembl ENSG00000007047
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0015630 (microtubule cytoskeleton)
GO:0036064 (ciliary basal body)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008017 (microtubule binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043015 (gamma-tubulin binding)
GO:0043130 (ubiquitin binding)
GO:0050321 (tau-protein kinase activity)
GO Biological Process GO:0000226 (microtubule cytoskeleton organization)
GO:0001578 (microtubule bundle formation)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007399 (nervous system development)
GO:0016310 (phosphorylation)
GO:0030010 (establishment of cell polarity)
GO:0030030 (cell projection organization)
GO:0043068 (positive regulation of programmed cell death)
GO:0051301 (cell division)
GO:0097711 (ciliary basal body-plasma membrane docking)
Wikipedia MARK4

Target Cross References - Protein

canSAR Q96L34
Human Protein Atlas ENSG00000007047
IntAct Q96L34
Guide to Pharmacology 2100
Open Targets ENSG00000007047
PharmGKB PA30641
Pharos Q96L34 (Tchem)
Reactome R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
UniProt Q8NG37 Q96JG7 Q96L34 Q96SQ2 Q9BYD8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001772 (KA1_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR015940 (UBA.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
IPR033624 (MARK/par1.)
Pfam PF00069 (Pkinase)
PF00627 (UBA)
PF02149 (KA1)

Target Cross References - Structure

PDBe 5ES1
CREDO 5ES1
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