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Target Report Card

Target Name and Classification

Target ID CHEMBL5753
Preferred Name Uncharacterized aarF domain-containing protein kinase 4
Synonyms AarF domain-containing protein kinase 4 | Atypical kinase COQ8B, mitochondrial | COQ8B | Coenzyme Q protein 8B | Synonyms=ADCK4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase abc1 family > atypical protein kinase abc1-a subfamily

Target Components

Component Description Relationship Accession
Atypical kinase COQ8B, mitochondrial SINGLE PROTEIN Q96D53

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123815
Ensembl ENSG00000123815
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006744 (ubiquinone biosynthetic process)
GO:0016310 (phosphorylation)
GO:0021692 (cerebellar Purkinje cell layer morphogenesis)

Target Cross References - Protein

canSAR Q96D53
Human Protein Atlas ENSG00000123815
IntAct Q96D53
Guide to Pharmacology 1928
Open Targets ENSG00000123815
PharmGKB PA134988974
Pharos Q96D53 (Tbio)
UniProt Q8TAJ1 Q96D53 Q9HA52

Target Cross References - Domain

InterPro IPR004147 (UbiB_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR034638 (COQ8B.)
IPR034646 (ADCK3_UbiB.)
Pfam PF03109 (ABC1)