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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5749
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms HPK1 | Hematopoietic progenitor kinase | MAP4K1 | MAPK/ERK kinase kinase kinase 1 | MEK kinase kinase 1 | MEKKK 1 | Mitogen-activated protein kinase kinase kinase kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase khs subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase kinase 1 SINGLE PROTEIN Q92918

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104814 ENSG00000282928
Ensembl ENSG00000104814 ENSG00000282928
GO Cellular Component GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008349 (MAP kinase kinase kinase kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000185 (activation of MAPKKK activity)
GO:0006468 (protein phosphorylation)
GO:0007257 (activation of JUN kinase activity)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008283 (cell proliferation)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0042981 (regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:1904628 (cellular response to phorbol 13-acetate 12-myristate)
Wikipedia MAP4K1

Target Cross References - Protein

canSAR Q92918
Human Protein Atlas ENSG00000104814 ENSG00000282928
IntAct Q92918
Guide to Pharmacology 2085
Open Targets ENSG00000104814 ENSG00000282928
PharmGKB PA30609
Pharos Q92918 (Tchem)
UniProt Q92918

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001180 (CNH_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR021160 (MAPKKKK.)
Pfam PF00069 (Pkinase)
PF00780 (CNH)
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