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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL5738
Target Type SINGLE PROTEIN
Preferred Name Fatty acid-binding protein, liver
Synonyms Fabp1 | Fatty acid-binding protein 1 | Fatty acid-binding protein, liver | L-FABP | Liver-type fatty acid-binding protein | SCP | Squalene- and sterol-carrier protein | Z-protein | p14
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • auxiliary transport protein > fatty acid binding protein family

Target Components

Component Description Relationship Accession
Fatty acid-binding protein, liver SINGLE PROTEIN P02692

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005782 (peroxisomal matrix)
GO:0005829 (cytosol)
GO:0032991 (macromolecular complex)
GO:0045179 (apical cortex)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0005324 (long-chain fatty acid transporter activity)
GO:0005504 (fatty acid binding)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008144 (drug binding)
GO:0008289 (lipid binding)
GO:0016209 (antioxidant activity)
GO:0032052 (bile acid binding)
GO:0051978 (lysophospholipid transporter activity)
GO Biological Process GO:0015909 (long-chain fatty acid transport)
GO:0032000 (positive regulation of fatty acid beta-oxidation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0050892 (intestinal absorption)
GO:0051345 (positive regulation of hydrolase activity)
GO:0051977 (lysophospholipid transport)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071456 (cellular response to hypoxia)
GO:0098869 (cellular oxidant detoxification)

Target Cross References - Protein

canSAR P02692
IntAct P02692
Guide to Pharmacology 2531
Reactome R-RNO-163560 (Triglyceride catabolism.)
R-RNO-400206 (Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).)
UniProt P02692

Target Cross References - Domain

InterPro IPR000463 (Fatty_acid-bd.)
IPR012674 (Calycin.)
IPR031259 (ILBP.)
IPR031276 (Lb-FABP.)

Target Cross References - Structure

PDBe 1LFO
CREDO 1LFO
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