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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5703
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase Srms
Synonyms C20orf148 | SRMS | Tyrosine-protein kinase Srms
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family > tyrosine protein kinase srm

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Srms SINGLE PROTEIN Q9H3Y6

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125508
Ensembl ENSG00000125508
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0009968 (negative regulation of signal transduction)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0045087 (innate immune response)

Target Cross References - Protein

canSAR Q9H3Y6
Human Protein Atlas ENSG00000125508
IntAct Q9H3Y6
Guide to Pharmacology 2207
Open Targets ENSG00000125508
PharmGKB PA36122
Pharos Q9H3Y6 (Tchem)
Reactome R-HSA-8849472 (PTK6 Down-Regulation.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt Q9H3Y6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF07714 (Pkinase_Tyr)
PF14604 (SH3_9)
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