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Target Report Card

Target Name and Classification

Target ID CHEMBL5699
Preferred Name Serine/threonine-protein kinase SIK2
Synonyms QIK | Qin-induced kinase | SIK-2 | SIK2 | SNF1LK2 | Salt-inducible kinase 2 | Serine/threonine-protein kinase SIK2 | Serine/threonine-protein kinase SNF1-like kinase 2 | Synonyms=KIAA0781
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase qik subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase SIK2 SINGLE PROTEIN Q9H0K1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170145
Ensembl ENSG00000170145
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0031588 (nucleotide-activated protein kinase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0032007 (negative regulation of TOR signaling)
GO:0035556 (intracellular signal transduction)
GO:0042149 (cellular response to glucose starvation)
GO:0046626 (regulation of insulin receptor signaling pathway)
GO:0046777 (protein autophosphorylation)
Wikipedia SNF1LK2

Target Cross References - Protein

canSAR Q9H0K1
Human Protein Atlas ENSG00000170145
IntAct Q9H0K1
Guide to Pharmacology 2198
Open Targets ENSG00000170145
PharmGKB PA164725750
Pharos Q9H0K1 (Tchem)
UniProt A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8 Q9H0K1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR015940 (UBA.)
IPR017090 (Ser/Thr_kinase_SIK1/2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR034672 (SIK.)
Pfam PF00069 (Pkinase)