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Target Report Card

Target Name and Classification

Target ID CHEMBL5685
Preferred Name Solute carrier family 22 member 1
Synonyms OCT1 | Organic cation transporter 1 | SLC22A1 | Solute carrier family 22 member 1 | hOCT1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc22 family of organic cation and anion transporters

Target Components

Component Description Relationship Accession
Solute carrier family 22 member 1 SINGLE PROTEIN O15245

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175003
Ensembl ENSG00000175003
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO Molecular Function GO:0005215 (transporter activity)
GO:0005277 (acetylcholine transmembrane transporter activity)
GO:0005329 (dopamine transmembrane transporter activity)
GO:0005333 (norepinephrine transmembrane transporter activity)
GO:0005515 (protein binding)
GO:0008504 (monoamine transmembrane transporter activity)
GO:0008513 (secondary active organic cation transmembrane transporter activity)
GO:0008514 (organic anion transmembrane transporter activity)
GO:0015101 (organic cation transmembrane transporter activity)
GO:0015651 (quaternary ammonium group transmembrane transporter activity)
GO:0022857 (transmembrane transporter activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006836 (neurotransmitter transport)
GO:0006855 (drug transmembrane transport)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0015695 (organic cation transport)
GO:0015697 (quaternary ammonium group transport)
GO:0015711 (organic anion transport)
GO:0015844 (monoamine transport)
GO:0015872 (dopamine transport)
GO:0015874 (norepinephrine transport)
GO:0048241 (epinephrine transport)
GO:0051260 (protein homooligomerization)
GO:0055085 (transmembrane transport)
GO:0072488 (ammonium transmembrane transport)
GO:1901374 (acetate ester transport)
Wikipedia SLC22A1

Target Cross References - Protein

Human Protein Atlas ENSG00000175003
IntAct O15245
Guide to Pharmacology 1019
Open Targets ENSG00000175003
PharmGKB PA329
Reactome R-HSA-112311 (Neurotransmitter clearance.)
R-HSA-181430 (Norepinephrine Neurotransmitter Release Cycle.)
R-HSA-2161517 (Abacavir transmembrane transport.)
R-HSA-442660 (Na+/Cl- dependent neurotransmitter transporters.)
R-HSA-549127 (Organic cation transport.)
UniProt A6NFF3 A8K1H2 C9JSU6 O15245 O15395 Q9NQD4

Target Cross References - Domain

InterPro IPR004749 (Orgcat_transp/SVOP.)
IPR005828 (MFS_sugar_transport-like.)
IPR005829 (Sugar_transporter_CS.)
IPR020846 (MFS_dom.)
IPR036259 (MFS_trans_sf.)
Pfam PF00083 (Sugar_tr)