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Target Report Card

Target Name and Classification

Target ID CHEMBL5665
Target Type SINGLE PROTEIN
Preferred Name Disintegrin and metalloproteinase domain-containing protein 8
Synonyms ADAM 8 | ADAM8 | CD_antigen=CD156a | Cell surface antigen MS2 | Disintegrin and metalloproteinase domain-containing protein 8 | MS2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 8 SINGLE PROTEIN P78325

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151651
Ensembl ENSG00000151651
GO Cellular Component GO:0002102 (podosome)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0032010 (phagolysosome)
GO:0032127 (dense core granule membrane)
GO:0042581 (specific granule)
GO:0070820 (tertiary granule)
GO:0071065 (alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex)
GO:0071133 (alpha9-beta1 integrin-ADAM8 complex)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0043621 (protein self-association)
GO:0046872 (metal ion binding)
GO:0050839 (cell adhesion molecule binding)
GO Biological Process GO:0000902 (cell morphogenesis)
GO:0001525 (angiogenesis)
GO:0002523 (leukocyte migration involved in inflammatory response)
GO:0002675 (positive regulation of acute inflammatory response)
GO:0002693 (positive regulation of cellular extravasation)
GO:0006508 (proteolysis)
GO:0006954 (inflammatory response)
GO:0010954 (positive regulation of protein processing)
GO:0016337 (single organismal cell-cell adhesion)
GO:0022407 (regulation of cell-cell adhesion)
GO:0022617 (extracellular matrix disassembly)
GO:0033089 (positive regulation of T cell differentiation in thymus)
GO:0035419 (activation of MAPK activity involved in innate immune response)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045780 (positive regulation of bone resorption)
GO:0045785 (positive regulation of cell adhesion)
GO:0048247 (lymphocyte chemotaxis)
GO:0050714 (positive regulation of protein secretion)
GO:0050729 (positive regulation of inflammatory response)
GO:0051044 (positive regulation of membrane protein ectodomain proteolysis)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0070245 (positive regulation of thymocyte apoptotic process)
GO:0071456 (cellular response to hypoxia)
GO:2000309 (positive regulation of tumor necrosis factor (ligand) superfamily member 11 production)
GO:2000391 (positive regulation of neutrophil extravasation)
GO:2000406 (positive regulation of T cell migration)
GO:2000415 (positive regulation of fibronectin-dependent thymocyte migration)
GO:2000418 (positive regulation of eosinophil migration)

Target Cross References - Protein

canSAR P78325
Human Protein Atlas ENSG00000151651
IntAct P78325
Guide to Pharmacology 1656
Open Targets ENSG00000151651
Reactome R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B4DVM6 H0YL36 H0YLR0 H0YN39 P78325

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR001590 (Peptidase_M12B.)
IPR001762 (Disintegrin_dom.)
IPR002870 (Peptidase_M12B_N.)
IPR006586 (ADAM_Cys-rich.)
IPR013032 (EGF-like_CS.)
IPR018358 (Disintegrin_CS.)
IPR024079 (MetalloPept_cat_dom.)
IPR034027 (Reprolysin_adamalysin.)
Pfam PF00200 (Disintegrin)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
PF08516 (ADAM_CR)

Target Cross References - Structure

PDBe 4DD8
CREDO 4DD8
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