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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5621
Target Type SINGLE PROTEIN
Preferred Name Dihydroorotate dehydrogenase
Synonyms DHOD | DHODase | DHOdehase | Dihydroorotate dehydrogenase (fumarate) | Dihydroorotate oxidase | URA1
Organism Saccharomyces cerevisiae S288c
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Dihydroorotate dehydrogenase (fumarate) SINGLE PROTEIN P28272

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0019898 (extrinsic component of membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004152 (dihydroorotate dehydrogenase activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
GO:1990663 (dihydroorotate dehydrogenase (fumarate) activity)
GO Biological Process GO:0006207 (de novo pyrimidine nucleobase biosynthetic process)
GO:0006221 (pyrimidine nucleotide biosynthetic process)
GO:0006222 (UMP biosynthetic process)
GO:0044205 (de novo UMP biosynthetic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P28272
IntAct P28272
Reactome R-SCE-500753 (Pyrimidine biosynthesis.)
UniProt D6VWY7 P28272 Q2XN75 Q70DC7

Target Cross References - Domain

InterPro IPR001295 (Dihydroorotate_DH_CS.)
IPR005720 (Dihydroorotate_DH.)
IPR012135 (Dihydroorotate_DH_1_2.)
IPR013785 (Aldolase_TIM.)
IPR023359 (Dihydro_DH_chainA_dom2.)
IPR024920 (Dihydroorotate_DH_1.)
IPR033886 (DHOD_1A.)
Pfam PF01180 (DHO_dh)
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