ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5619
Target Type SINGLE PROTEIN
Preferred Name DNA-(apurinic or apyrimidinic site) lyase
Synonyms AP endonuclease 1 | APE | APE-1 | APE1 | APEN | APEX nuclease | APEX | APEX1 | APX | Apurinic-apyrimidinic endonuclease 1 | DNA-(apurinic or apyrimidinic site) lyase | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial | HAP1 | REF-1 | REF1 | Redox factor-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA-(apurinic or apyrimidinic site) lyase SINGLE PROTEIN P27695

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100823
Ensembl ENSG00000100823
GO Cellular Component GO:0000784 (nuclear chromosome, telomeric region)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005813 (centrosome)
GO:0005840 (ribosome)
GO:0016607 (nuclear speck)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003684 (damaged DNA binding)
GO:0003691 (double-stranded telomeric DNA binding)
GO:0003713 (transcription coactivator activity)
GO:0003714 (transcription corepressor activity)
GO:0003723 (RNA binding)
GO:0003906 (DNA-(apurinic or apyrimidinic site) lyase activity)
GO:0004518 (nuclease activity)
GO:0004519 (endonuclease activity)
GO:0004520 (endodeoxyribonuclease activity)
GO:0004521 (endoribonuclease activity)
GO:0004523 (RNA-DNA hybrid ribonuclease activity)
GO:0004527 (exonuclease activity)
GO:0004528 (phosphodiesterase I activity)
GO:0004844 (uracil DNA N-glycosylase activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0008309 (double-stranded DNA exodeoxyribonuclease activity)
GO:0008311 (double-stranded DNA 3'-5' exodeoxyribonuclease activity)
GO:0008408 (3'-5' exonuclease activity)
GO:0016491 (oxidoreductase activity)
GO:0016787 (hydrolase activity)
GO:0016829 (lyase activity)
GO:0016890 (site-specific endodeoxyribonuclease activity, specific for altered base)
GO:0031490 (chromatin DNA binding)
GO:0032403 (protein complex binding)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO:0051059 (NF-kappaB binding)
GO Biological Process GO:0000723 (telomere maintenance)
GO:0006281 (DNA repair)
GO:0006284 (base-excision repair)
GO:0006286 (base-excision repair, base-free sugar-phosphate removal)
GO:0006310 (DNA recombination)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007568 (aging)
GO:0010243 (response to organonitrogen compound)
GO:0014912 (negative regulation of smooth muscle cell migration)
GO:0042493 (response to drug)
GO:0043488 (regulation of mRNA stability)
GO:0045454 (cell redox homeostasis)
GO:0045739 (positive regulation of DNA repair)
GO:0055114 (oxidation-reduction process)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071320 (cellular response to cAMP)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0071417 (cellular response to organonitrogen compound)
GO:0080111 (DNA demethylation)
GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic)
GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle)
GO:1903507 (negative regulation of nucleic acid-templated transcription)
Wikipedia APEX1

Target Cross References - Protein

canSAR P27695
Human Protein Atlas ENSG00000100823
IntAct P27695
Open Targets ENSG00000100823
PharmGKB PA201059
Reactome R-HSA-110357 (Displacement of DNA glycosylase by APEX1.)
R-HSA-110362 (POLB-Dependent Long Patch Base Excision Repair.)
R-HSA-110373 (Resolution of AP sites via the multiple-nucleotide patch replacement pathway.)
R-HSA-5651801 (PCNA-Dependent Long Patch Base Excision Repair.)
R-HSA-73930 (Abasic sugar-phosphate removal via the single-nucleotide replacement pathway.)
R-HSA-73933 (Resolution of Abasic Sites (AP sites).)
UniProt P27695 Q969L5 Q99775

Target Cross References - Domain

InterPro IPR004808 (AP_endonuc_1.)
IPR005135 (Endo/exonuclease/phosphatase.)
IPR020847 (AP_endonuclease_F1_BS.)
IPR020848 (AP_endonuclease_F1_CS.)
Pfam PF03372 (Exo_endo_phos)

Target Cross References - Structure

PDBe 1BIX 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0
CREDO 1BIX 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0
spacer
spacer