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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5616
Target Type SINGLE PROTEIN
Preferred Name Activin receptor type-2A
Synonyms ACTR-IIA | ACTRIIA | ACVR2 | ACVR2A | Activin receptor type IIA | Activin receptor type-2A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 2 subfamily

Target Components

Component Description Relationship Accession
Activin receptor type-2A SINGLE PROTEIN P27037

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121989
Ensembl ENSG00000121989
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0034673 (inhibin-betaglycan-ActRII complex)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0015026 (coreceptor activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017002 (activin-activated receptor activity)
GO:0019838 (growth factor binding)
GO:0030165 (PDZ domain binding)
GO:0034711 (inhibin binding)
GO:0043621 (protein self-association)
GO:0046872 (metal ion binding)
GO:0048185 (activin binding)
GO:0098821 (BMP receptor activity)
GO Biological Process GO:0001702 (gastrulation with mouth forming second)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007283 (spermatogenesis)
GO:0007368 (determination of left/right symmetry)
GO:0007498 (mesoderm development)
GO:0008584 (male gonad development)
GO:0009952 (anterior/posterior pattern specification)
GO:0009966 (regulation of signal transduction)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0030510 (regulation of BMP signaling pathway)
GO:0032924 (activin receptor signaling pathway)
GO:0032927 (positive regulation of activin receptor signaling pathway)
GO:0042713 (sperm ejaculation)
GO:0043084 (penile erection)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048706 (embryonic skeletal system development)
GO:0050999 (regulation of nitric-oxide synthase activity)
GO:0060011 (Sertoli cell proliferation)
GO:0071773 (cellular response to BMP stimulus)
Wikipedia ACVR2A

Target Cross References - Protein

canSAR P27037
Human Protein Atlas ENSG00000121989
IntAct P27037
Guide to Pharmacology 1791
Open Targets ENSG00000121989
PharmGKB PA24494
Pharos P27037 (Tbio)
Reactome R-HSA-1181150 (Signaling by NODAL.)
R-HSA-1433617 (Regulation of signaling by NODAL.)
R-HSA-1502540 (Signaling by Activin.)
R-HSA-201451 (Signaling by BMP.)
UniProt B2RAB8 B4DWQ2 D3DP85 P27037 Q53TH4 Q6NWV2 Q92474

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000472 (Activin_recp.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF01064 (Activin_recp)

Target Cross References - Structure

PDBe 3Q4T 3SOC 4ASX
CREDO 3Q4T 3SOC 4ASX
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