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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5586
Target Type SINGLE PROTEIN
Preferred Name Carbonyl reductase [NADPH] 1
Synonyms 15-hydroxyprostaglandin dehydrogenase [NADP(+)] | CBR | CBR1 | CRN | Carbonyl reductase [NADPH] 1 | NADPH-dependent carbonyl reductase 1 | Prostaglandin 9-ketoreductase | Prostaglandin-E(2) 9-reductase | SDR21C1 | Short chain dehydrogenase/reductase family 21C member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Carbonyl reductase [NADPH] 1 SINGLE PROTEIN P16152

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000159228
Ensembl ENSG00000159228
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO:1903561 (extracellular vesicle)
GO Molecular Function GO:0004090 (carbonyl reductase (NADPH) activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
GO:0047021 (15-hydroxyprostaglandin dehydrogenase (NADP+) activity)
GO:0050221 (prostaglandin-E2 9-reductase activity)
GO Biological Process GO:0017144 (drug metabolic process)
GO:0019371 (cyclooxygenase pathway)
GO:0030855 (epithelial cell differentiation)
GO:0042373 (vitamin K metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CBR1

Target Cross References - Protein

canSAR P16152
Human Protein Atlas ENSG00000159228
IntAct P16152
Guide to Pharmacology 1383
Open Targets ENSG00000159228
PharmGKB PA26121
Reactome R-HSA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt B2RBZ7 B4DFK7 P16152 Q3LHW8

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR020904 (Sc_DH/Rdtase_CS.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00106 (adh_short)

Target Cross References - Structure

PDBe 1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D
CREDO 1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D
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