ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5582
Target Type SINGLE PROTEIN
Preferred Name Hormone-sensitive lipase
Synonyms HSL | Hormone-sensitive lipase | Lipe
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hormone-sensitive lipase SINGLE PROTEIN P15304

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005811 (lipid droplet)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO Molecular Function GO:0005515 (protein binding)
GO:0016298 (lipase activity)
GO:0016787 (hydrolase activity)
GO:0016788 (hydrolase activity, acting on ester bonds)
GO:0033878 (hormone-sensitive lipase activity)
GO:0042134 (rRNA primary transcript binding)
GO:0047372 (acylglycerol lipase activity)
GO Biological Process GO:0006361 (transcription initiation from RNA polymerase I promoter)
GO:0006363 (termination of RNA polymerase I transcription)
GO:0006629 (lipid metabolic process)
GO:0007565 (female pregnancy)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0016042 (lipid catabolic process)
GO:0019433 (triglyceride catabolic process)
GO:0042493 (response to drug)

Target Cross References - Protein

canSAR P15304
IntAct P15304
UniProt P15304 Q6LCQ2

Target Cross References - Domain

InterPro IPR002168 (Lipase_GDXG_HIS_AS.)
IPR010468 (HSL_N.)
IPR013094 (AB_hydrolase_3.)
IPR029058 (AB_hydrolase.)
IPR033140 (Lipase_GDXG_put_SER_AS.)
Pfam PF06350 (HSL_N)
PF07859 (Abhydrolase_3)
spacer
spacer