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Target Report Card

Target Name and Classification

Target ID CHEMBL5579
Preferred Name Citron Rho-interacting kinase
Synonyms CIT | CRIK | CRIK | Citron Rho-interacting kinase | KIAA0949 | STK21 | Serine/threonine-protein kinase 21
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase dmpk family > agc protein kinase crik subfamily

Target Components

Component Description Relationship Accession
Citron Rho-interacting kinase SINGLE PROTEIN O14578

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122966
Ensembl ENSG00000122966
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030496 (midbody)
GO:0031985 (Golgi cisterna)
GO:0032154 (cleavage furrow)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017048 (Rho GTPase binding)
GO:0017124 (SH3 domain binding)
GO:0030165 (PDZ domain binding)
GO:0046872 (metal ion binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000278 (mitotic cell cycle)
GO:0000281 (mitotic cytokinesis)
GO:0006468 (protein phosphorylation)
GO:0007030 (Golgi organization)
GO:0007049 (cell cycle)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0008064 (regulation of actin polymerization or depolymerization)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0032467 (positive regulation of cytokinesis)
GO:0035556 (intracellular signal transduction)
GO:0048699 (generation of neurons)
GO:0051301 (cell division)
GO:0051402 (neuron apoptotic process)
Wikipedia CIT_(gene)

Target Cross References - Protein

canSAR O14578
Human Protein Atlas ENSG00000122966
IntAct O14578
Guide to Pharmacology 1509
Open Targets ENSG00000122966
PharmGKB PA26522
Pharos O14578 (Tbio)
Reactome R-HSA-5625900 (RHO GTPases activate CIT.)
UniProt O14578 Q2M5E1 Q6XUH8 Q86UQ9 Q9UPZ7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001180 (CNH_dom.)
IPR001849 (PH_domain.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011993 (PH-like_dom_sf.)
IPR017405 (Citron_Rho-interacting_kinase.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR037708 (CRIK_dom.)
Pfam PF00069 (Pkinase)
PF00169 (PH)
PF00780 (CNH)