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Target Report Card

Target Name and Classification

Target ID CHEMBL5575
Target Type SINGLE PROTEIN
Preferred Name Lysyl-tRNA synthetase
Synonyms KARS | KIAA0070 | LysRS | Lysine--tRNA ligase | Lysyl-tRNA synthetase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Lysine--tRNA ligase SINGLE PROTEIN Q15046

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065427
Ensembl ENSG00000065427
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0017101 (aminoacyl-tRNA synthetase multienzyme complex)
GO Molecular Function GO:0000049 (tRNA binding)
GO:0000166 (nucleotide binding)
GO:0003676 (nucleic acid binding)
GO:0003877 (ATP adenylyltransferase activity)
GO:0004812 (aminoacyl-tRNA ligase activity)
GO:0004824 (lysine-tRNA ligase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016597 (amino acid binding)
GO:0016740 (transferase activity)
GO:0016874 (ligase activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0002276 (basophil activation involved in immune response)
GO:0002741 (positive regulation of cytokine secretion involved in immune response)
GO:0006412 (translation)
GO:0006418 (tRNA aminoacylation for protein translation)
GO:0006430 (lysyl-tRNA aminoacylation)
GO:0008033 (tRNA processing)
GO:0008285 (negative regulation of cell proliferation)
GO:0010165 (response to X-ray)
GO:0010759 (positive regulation of macrophage chemotaxis)
GO:0015966 (diadenosine tetraphosphate biosynthetic process)
GO:0016032 (viral process)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0043032 (positive regulation of macrophage activation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:1900017 (positive regulation of cytokine production involved in inflammatory response)
GO:1900745 (positive regulation of p38MAPK cascade)
GO:1905050 (positive regulation of metallopeptidase activity)
Wikipedia KARS_(gene)

Target Cross References - Protein

canSAR Q15046
CGD Charcot-Marie-Tooth disease, recessive intermediate B
Human Protein Atlas ENSG00000065427
IntAct Q15046
Open Targets ENSG00000065427
PharmGKB PA30016
Reactome R-HSA-2408517 (SeMet incorporation into proteins.)
R-HSA-379716 (Cytosolic tRNA aminoacylation.)
R-HSA-379726 (Mitochondrial tRNA aminoacylation.)
UniProt A8MSK1 D3DUK4 O14946 Q15046 Q96J25 Q9HB23

Target Cross References - Domain

InterPro IPR002313 (Lys-tRNA-ligase_II.)
IPR004364 (aa-tRNA-synt_II.)
IPR004365 (NA-bd_OB_tRNA.)
IPR006195 (aa-tRNA-synth_II.)
IPR012340 (NA-bd_OB-fold.)
IPR018149 (Lys-tRNA-synth_II_C.)
IPR034762 (Lys-tRNA-ligase_II_bac/euk.)
Pfam PF00152 (tRNA-synt_2)
PF01336 (tRNA_anti-codon)

Target Cross References - Structure

PDBe 3BJU 4DPG 4YCU 4YCW
CREDO 3BJU 4DPG 4YCU 4YCW
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