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Target Report Card

Target Name and Classification

Target ID CHEMBL5564
Preferred Name DNA topoisomerase II beta
Synonyms DNA topoisomerase 2-beta | DNA topoisomerase II, beta isozyme | Top2b
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA topoisomerase 2-beta SINGLE PROTEIN Q64511

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000792 (heterochromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005730 (nucleolus)
GO:0005829 (cytosol)
GO:1990904 (ribonucleoprotein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003916 (DNA topoisomerase activity)
GO:0003918 (DNA topoisomerase type II (ATP-hydrolyzing) activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016853 (isomerase activity)
GO:0019899 (enzyme binding)
GO:0042826 (histone deacetylase binding)
GO:0043021 (ribonucleoprotein complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0061505 (DNA topoisomerase II activity)
GO Biological Process GO:0000712 (resolution of meiotic recombination intermediates)
GO:0000819 (sister chromatid segregation)
GO:0001764 (neuron migration)
GO:0006259 (DNA metabolic process)
GO:0006265 (DNA topological change)
GO:0007409 (axonogenesis)
GO:0007569 (cell aging)
GO:0030900 (forebrain development)
GO:0044774 (mitotic DNA integrity checkpoint)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071318 (cellular response to ATP)
GO:2001034 (positive regulation of double-strand break repair via nonhomologous end joining)

Target Cross References - Protein

canSAR Q64511
IntAct Q64511
Reactome R-MMU-4615885 (SUMOylation of DNA replication proteins.)
UniProt Q64511 Q7TQG4

Target Cross References - Domain

InterPro IPR001241 (Topo_IIA.)
IPR002205 (Topo_IIA_A/C.)
IPR003594 (HATPase_C.)
IPR006171 (TOPRIM_domain.)
IPR012542 (DTHCT.)
IPR013506 (Topo_IIA_bsu_dom2.)
IPR013757 (Topo_IIA_A_a_sf.)
IPR013758 (Topo_IIA_A/C_ab.)
IPR013759 (Topo_IIA_B_C.)
IPR013760 (Topo_IIA-like_dom_sf.)
IPR014721 (Ribosomal_S5_D2-typ_fold_subgr.)
IPR018522 (TopoIIA_CS.)
IPR020568 (Ribosomal_S5_D2-typ_fold.)
IPR031660 (TOPRIM_C.)
IPR034157 (TOPRIM_TopoII.)
IPR036890 (HATPase_C_sf.)
Pfam PF00204 (DNA_gyraseB)
PF00521 (DNA_topoisoIV)
PF01751 (Toprim)
PF02518 (HATPase_c)
PF08070 (DTHCT)
PF16898 (TOPRIM_C)