ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5564
Target Type SINGLE PROTEIN
Preferred Name DNA topoisomerase II beta
Synonyms DNA topoisomerase 2-beta | DNA topoisomerase II, beta isozyme | Top2b
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA topoisomerase 2-beta SINGLE PROTEIN Q64511

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000792 (heterochromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005730 (nucleolus)
GO:0005829 (cytosol)
GO:1990904 (ribonucleoprotein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003916 (DNA topoisomerase activity)
GO:0003918 (DNA topoisomerase type II (ATP-hydrolyzing) activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016853 (isomerase activity)
GO:0019899 (enzyme binding)
GO:0042826 (histone deacetylase binding)
GO:0043021 (ribonucleoprotein complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0061505 (DNA topoisomerase II activity)
GO Biological Process GO:0000712 (resolution of meiotic recombination intermediates)
GO:0000819 (sister chromatid segregation)
GO:0001764 (neuron migration)
GO:0006259 (DNA metabolic process)
GO:0006265 (DNA topological change)
GO:0007409 (axonogenesis)
GO:0007569 (cell aging)
GO:0030900 (forebrain development)
GO:0044774 (mitotic DNA integrity checkpoint)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071318 (cellular response to ATP)
GO:2001034 (positive regulation of double-strand break repair via nonhomologous end joining)

Target Cross References - Protein

canSAR Q64511
IntAct Q64511
Reactome R-MMU-4615885 (SUMOylation of DNA replication proteins.)
UniProt Q64511 Q7TQG4

Target Cross References - Domain

InterPro IPR001241 (Topo_IIA.)
IPR002205 (Topo_IIA_A/C.)
IPR003594 (HATPase_C.)
IPR006171 (TOPRIM_domain.)
IPR012542 (DTHCT.)
IPR013506 (Topo_IIA_bsu_dom2.)
IPR013757 (Topo_IIA_A_a_sf.)
IPR013758 (Topo_IIA_A/C_ab.)
IPR013759 (Topo_IIA_B_C.)
IPR013760 (Topo_IIA-like_dom_sf.)
IPR014721 (Ribosomal_S5_D2-typ_fold_subgr.)
IPR018522 (TopoIIA_CS.)
IPR020568 (Ribosomal_S5_D2-typ_fold.)
IPR031660 (TOPRIM_C.)
IPR034157 (TOPRIM_TopoII.)
IPR036890 (HATPase_C_sf.)
Pfam PF00204 (DNA_gyraseB)
PF00521 (DNA_topoisoIV)
PF01751 (Toprim)
PF02518 (HATPase_c)
PF08070 (DTHCT)
PF16898 (TOPRIM_C)
spacer
spacer