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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5555
Target Type SINGLE PROTEIN
Preferred Name Acyl-CoA desaturase
Synonyms Acyl-CoA desaturase | Delta(9)-desaturase | Delta-9 desaturase | Fatty acid desaturase | SCD | Stearoyl-CoA desaturase | hSCD1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acyl-CoA desaturase SINGLE PROTEIN O00767

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000099194
Ensembl ENSG00000099194
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004768 (stearoyl-CoA 9-desaturase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016717 (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006636 (unsaturated fatty acid biosynthetic process)
GO:0035338 (long-chain fatty-acyl-CoA biosynthetic process)
GO:0055114 (oxidation-reduction process)
Wikipedia Stearoyl-CoA_desaturase-1

Target Cross References - Protein

canSAR O00767
Human Protein Atlas ENSG00000099194
IntAct O00767
Open Targets ENSG00000099194
PharmGKB PA34984
Reactome R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-75105 (Fatty Acyl-CoA Biosynthesis.)
UniProt B2R5U0 D3DR68 O00767 Q16150 Q53GR9 Q5W037 Q5W038 Q6GSS4 Q96KF6 Q9BS07 Q9Y695

Target Cross References - Domain

InterPro IPR001522 (FADS-1_CS.)
IPR015876 (Acyl-CoA_DS.)

Target Cross References - Structure

PDBe 4ZYO
CREDO 4ZYO
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