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Target Report Card

Target Name and Classification

Target ID CHEMBL5553
Target Type SINGLE PROTEIN
Preferred Name ATP-dependent RNA helicase DDX3X
Synonyms ATP-dependent RNA helicase DDX3X | DBX | DDX3 | DDX3X | DEAD box protein 3, X-chromosomal | DEAD box, X isoform | HLP2 | Helicase-like protein 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
ATP-dependent RNA helicase DDX3X SINGLE PROTEIN O00571

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000215301
Ensembl ENSG00000215301
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0005852 (eukaryotic translation initiation factor 3 complex)
GO:0010494 (cytoplasmic stress granule)
GO:0016020 (membrane)
GO:0016607 (nuclear speck)
GO:0022627 (cytosolic small ribosomal subunit)
GO:0034774 (secretory granule lumen)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003723 (RNA binding)
GO:0003924 (GTPase activity)
GO:0004003 (ATP-dependent DNA helicase activity)
GO:0004004 (ATP-dependent RNA helicase activity)
GO:0004386 (helicase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0008143 (poly(A) binding)
GO:0008190 (eukaryotic initiation factor 4E binding)
GO:0016787 (hydrolase activity)
GO:0016887 (ATPase activity)
GO:0017111 (nucleoside-triphosphatase activity)
GO:0031369 (translation initiation factor binding)
GO:0033592 (RNA strand annealing activity)
GO:0035613 (RNA stem-loop binding)
GO:0043024 (ribosomal small subunit binding)
GO:0043273 (CTPase activity)
GO:0043539 (protein serine/threonine kinase activator activity)
GO:0045296 (cadherin binding)
GO:0048027 (mRNA 5'-UTR binding)
GO Biological Process GO:0002376 (immune system process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006413 (translational initiation)
GO:0006417 (regulation of translation)
GO:0006915 (apoptotic process)
GO:0007059 (chromosome segregation)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0009615 (response to virus)
GO:0010501 (RNA secondary structure unwinding)
GO:0010628 (positive regulation of gene expression)
GO:0016032 (viral process)
GO:0016055 (Wnt signaling pathway)
GO:0017148 (negative regulation of translation)
GO:0030307 (positive regulation of cell growth)
GO:0030308 (negative regulation of cell growth)
GO:0031333 (negative regulation of protein complex assembly)
GO:0032508 (DNA duplex unwinding)
GO:0032728 (positive regulation of interferon-beta production)
GO:0034063 (stress granule assembly)
GO:0035556 (intracellular signal transduction)
GO:0042254 (ribosome biogenesis)
GO:0042256 (mature ribosome assembly)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043312 (neutrophil degranulation)
GO:0045070 (positive regulation of viral genome replication)
GO:0045087 (innate immune response)
GO:0045727 (positive regulation of translation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045948 (positive regulation of translational initiation)
GO:0071243 (cellular response to arsenic-containing substance)
GO:0071470 (cellular response to osmotic stress)
GO:0071651 (positive regulation of chemokine (C-C motif) ligand 5 production)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle)
GO:1903608 (protein localization to cytoplasmic stress granule)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
Wikipedia DDX3X

Target Cross References - Protein

canSAR O00571
Human Protein Atlas ENSG00000215301
IntAct O00571
Open Targets ENSG00000215301
PharmGKB PA27216
Reactome R-HSA-6798695 (Neutrophil degranulation.)
UniProt A8K538 B4E3E8 O00571 O15536

Target Cross References - Domain

InterPro IPR000629 (RNA-helicase_DEAD-box_CS.)
IPR001650 (Helicase_C.)
IPR011545 (DEAD/DEAH_box_helicase_dom.)
IPR014001 (Helicase_ATP-bd.)
IPR014014 (RNA_helicase_DEAD_Q_motif.)
IPR027417 (P-loop_NTPase.)
Pfam PF00270 (DEAD)
PF00271 (Helicase_C)

Target Cross References - Structure

PDBe 2I4I 2JGN 3JRV 4O2C 4O2E 4O2F 4PX9 4PXA 5E7I 5E7J 5E7M
CREDO 2I4I 2JGN 3JRV 4O2C 4O2E 4O2F 4PX9 4PXA 5E7I 5E7J 5E7M
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