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Target Report Card

Target Name and Classification

Target ID CHEMBL5552
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase 25
Synonyms SOK-1 | SOK1 | STK25 | Serine/threonine-protein kinase 25 | Ste20-like kinase | Ste20/oxidant stress response kinase 1 | Sterile 20/oxidant stress-response kinase 1 | YSK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase ysk subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase 25 SINGLE PROTEIN O00506

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115694
Ensembl ENSG00000115694
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008349 (MAP kinase kinase kinase kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000185 (activation of MAPKKK activity)
GO:0006468 (protein phosphorylation)
GO:0006979 (response to oxidative stress)
GO:0007163 (establishment or maintenance of cell polarity)
GO:0007165 (signal transduction)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0032874 (positive regulation of stress-activated MAPK cascade)
GO:0036481 (intrinsic apoptotic signaling pathway in response to hydrogen peroxide)
GO:0042542 (response to hydrogen peroxide)
GO:0042981 (regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0048812 (neuron projection morphogenesis)
GO:0050772 (positive regulation of axonogenesis)
GO:0051645 (Golgi localization)
GO:0051683 (establishment of Golgi localization)
GO:0090168 (Golgi reassembly)
Wikipedia STK25

Target Cross References - Protein

canSAR O00506
Human Protein Atlas ENSG00000115694
IntAct O00506
Guide to Pharmacology 2218
Open Targets ENSG00000115694
PharmGKB PA36211
Pharos O00506 (Tbio)
UniProt A8K6Z3 A8K7D2 B7Z9K1 O00506 Q15522 Q5BJF1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR035060 (STK_STK25.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2XIK 3W8H 4NZW
CREDO 2XIK 3W8H 4NZW
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