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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5546
Target Type SINGLE PROTEIN
Preferred Name Myosin IIIA
Synonyms MYO3A | Myosin-IIIa
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase ninac subfamily

Target Components

Component Description Relationship Accession
Myosin-IIIa SINGLE PROTEIN Q8NEV4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000095777
Ensembl ENSG00000095777
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0016459 (myosin complex)
GO:0030175 (filopodium)
GO:0031941 (filamentous actin)
GO:0032420 (stereocilium)
GO:0032426 (stereocilium tip)
GO:0032433 (filopodium tip)
GO:0042995 (cell projection)
GO Molecular Function GO:0000146 (microfilament motor activity)
GO:0000166 (nucleotide binding)
GO:0003774 (motor activity)
GO:0003779 (actin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030898 (actin-dependent ATPase activity)
GO:0043531 (ADP binding)
GO:0060002 (plus-end directed microfilament motor activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007601 (visual perception)
GO:0007605 (sensory perception of sound)
GO:0016310 (phosphorylation)
GO:0046777 (protein autophosphorylation)
GO:0050896 (response to stimulus)
GO:0090103 (cochlea morphogenesis)
Wikipedia MYO3A

Target Cross References - Protein

canSAR Q8NEV4
CGD Deafness, autosomal recessive 30
Human Protein Atlas ENSG00000095777
IntAct Q8NEV4
Guide to Pharmacology 2112
Open Targets ENSG00000095777
PharmGKB PA31405
Pharos Q8NEV4 (Tbio)
UniProt Q4G0X2 Q5VZ28 Q8NEV4 Q8WX17 Q9NYS8

Target Cross References - Domain

InterPro IPR000048 (IQ_motif_EF-hand-BS.)
IPR000719 (Prot_kinase_dom.)
IPR001609 (Myosin_head_motor_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR027417 (P-loop_NTPase.)
IPR036083 (MYSc_Myo3.)
Pfam PF00063 (Myosin_head)
PF00069 (Pkinase)
PF00612 (IQ)
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