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Target Report Card

Target Name and Classification

Target ID CHEMBL5524
Preferred Name Protein-arginine N-methyltransferase 1
Synonyms HMT2 | HRMT1L2 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > protein methyltransferase > protein arginine methyltransferase

Target Components

Component Description Relationship Accession
Protein arginine N-methyltransferase 1 SINGLE PROTEIN Q99873

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000126457
Ensembl ENSG00000126457
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0034709 (methylosome)
GO Molecular Function GO:0003723 (RNA binding)
GO:0005515 (protein binding)
GO:0008168 (methyltransferase activity)
GO:0008170 (N-methyltransferase activity)
GO:0008276 (protein methyltransferase activity)
GO:0008327 (methyl-CpG binding)
GO:0016274 (protein-arginine N-methyltransferase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0035242 (protein-arginine omega-N asymmetric methyltransferase activity)
GO:0042054 (histone methyltransferase activity)
GO:0042802 (identical protein binding)
GO:0044020 (histone methyltransferase activity (H4-R3 specific))
GO:0048273 (mitogen-activated protein kinase p38 binding)
GO Biological Process GO:0006355 (regulation of transcription, DNA-templated)
GO:0006479 (protein methylation)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007166 (cell surface receptor signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0016571 (histone methylation)
GO:0018216 (peptidyl-arginine methylation)
GO:0019919 (peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)
GO:0031175 (neuron projection development)
GO:0032259 (methylation)
GO:0035246 (peptidyl-arginine N-methylation)
GO:0043985 (histone H4-R3 methylation)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045652 (regulation of megakaryocyte differentiation)
GO:0045653 (negative regulation of megakaryocyte differentiation)
GO:0046985 (positive regulation of hemoglobin biosynthetic process)
GO:1900745 (positive regulation of p38MAPK cascade)
Wikipedia PRMT1

Target Cross References - Protein

canSAR Q99873
Human Protein Atlas ENSG00000126457
IntAct Q99873
Guide to Pharmacology 1252
Open Targets ENSG00000126457
PharmGKB PA29461
Reactome R-HSA-3214858 (RMTs methylate histone arginines.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
R-HSA-8936459 (RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.)
UniProt B4E3C3 G5E9B6 Q15529 Q2VP93 Q6LEU5 Q8WUW5 Q99872 Q99873 Q99874 Q9NZ04 Q9NZ05 Q9NZ06

Target Cross References - Domain

InterPro IPR025799 (Arg_MeTrfase.)
IPR029063 (SAM-dependent_MTases.)