ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5518
Preferred Name Misshapen-like kinase 1
Synonyms GCK family kinase MiNK | MAP4K6 | MAPK/ERK kinase kinase kinase 6 | MEK kinase kinase 6 | MEKKK 6 | MINK | MINK1 | Misshapen-like kinase 1 | Misshapen/NIK-related kinase | Mitogen-activated protein kinase kinase kinase kinase 6 | Synonyms=B55 | YSK2 | ZC3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase msn subfamily

Target Components

Component Description Relationship Accession
Misshapen-like kinase 1 SINGLE PROTEIN Q8N4C8

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430890 Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141503
Ensembl ENSG00000141503
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0042995 (cell projection)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008349 (MAP kinase kinase kinase kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000185 (activation of MAPKKK activity)
GO:0001952 (regulation of cell-matrix adhesion)
GO:0006468 (protein phosphorylation)
GO:0007254 (JNK cascade)
GO:0007268 (chemical synaptic transmission)
GO:0007275 (multicellular organism development)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0022407 (regulation of cell-cell adhesion)
GO:0030033 (microvillus assembly)
GO:0030334 (regulation of cell migration)
GO:0031532 (actin cytoskeleton reorganization)
GO:0042981 (regulation of apoptotic process)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0048812 (neuron projection morphogenesis)
GO:0048813 (dendrite morphogenesis)
GO:1900745 (positive regulation of p38MAPK cascade)
GO:2000311 (regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity)
Wikipedia MINK1

Target Cross References - Protein

Human Protein Atlas ENSG00000141503
IntAct Q8N4C8
Guide to Pharmacology 2103
Open Targets ENSG00000141503
PharmGKB PA134910641
Pharos Q8N4C8 (Tchem)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
UniProt D3DTK3 D3DTK4 Q5U8Z0 Q8N4C8 Q9P1X1 Q9P2R8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001180 (CNH_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00780 (CNH)