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Target Report Card

Target Name and Classification

Target ID CHEMBL5517
Preferred Name Secreted frizzled-related protein 1
Synonyms FRP | FRP-1 | FRP1 | SARP-2 | SARP2 | SFRP1 | Secreted apoptosis-related protein 2 | Secreted frizzled-related protein 1 | sFRP-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Secreted frizzled-related protein 1 SINGLE PROTEIN Q8N474

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104332
Ensembl ENSG00000104332
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016021 (integral component of membrane)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005109 (frizzled binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008201 (heparin binding)
GO:0017147 (Wnt-protein binding)
GO:0042802 (identical protein binding)
GO:0042813 (Wnt-activated receptor activity)
GO Biological Process GO:0001649 (osteoblast differentiation)
GO:0001657 (ureteric bud development)
GO:0001756 (somitogenesis)
GO:0001843 (neural tube closure)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0006508 (proteolysis)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0008585 (female gonad development)
GO:0009267 (cellular response to starvation)
GO:0009950 (dorsal/ventral axis specification)
GO:0009952 (anterior/posterior pattern specification)
GO:0010564 (regulation of cell cycle process)
GO:0010629 (negative regulation of gene expression)
GO:0010719 (negative regulation of epithelial to mesenchymal transition)
GO:0010975 (regulation of neuron projection development)
GO:0014034 (neural crest cell fate commitment)
GO:0014070 (response to organic cyclic compound)
GO:0016055 (Wnt signaling pathway)
GO:0021915 (neural tube development)
GO:0030097 (hemopoiesis)
GO:0030154 (cell differentiation)
GO:0030177 (positive regulation of Wnt signaling pathway)
GO:0030178 (negative regulation of Wnt signaling pathway)
GO:0030279 (negative regulation of ossification)
GO:0030307 (positive regulation of cell growth)
GO:0030308 (negative regulation of cell growth)
GO:0030336 (negative regulation of cell migration)
GO:0030514 (negative regulation of BMP signaling pathway)
GO:0033689 (negative regulation of osteoblast proliferation)
GO:0035019 (somatic stem cell population maintenance)
GO:0042493 (response to drug)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043508 (negative regulation of JUN kinase activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0044344 (cellular response to fibroblast growth factor stimulus)
GO:0044345 (stromal-epithelial cell signaling involved in prostate gland development)
GO:0045578 (negative regulation of B cell differentiation)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045671 (negative regulation of osteoclast differentiation)
GO:0045765 (regulation of angiogenesis)
GO:0045880 (positive regulation of smoothened signaling pathway)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046546 (development of primary male sexual characteristics)
GO:0046676 (negative regulation of insulin secretion)
GO:0046851 (negative regulation of bone remodeling)
GO:0048147 (negative regulation of fibroblast proliferation)
GO:0048546 (digestive tract morphogenesis)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
GO:0060218 (hematopoietic stem cell differentiation)
GO:0060346 (bone trabecula formation)
GO:0060527 (prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)
GO:0060687 (regulation of branching involved in prostate gland morphogenesis)
GO:0060766 (negative regulation of androgen receptor signaling pathway)
GO:0071305 (cellular response to vitamin D)
GO:0071347 (cellular response to interleukin-1)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:0071391 (cellular response to estrogen stimulus)
GO:0071392 (cellular response to estradiol stimulus)
GO:0071456 (cellular response to hypoxia)
GO:0071481 (cellular response to X-ray)
GO:0071504 (cellular response to heparin)
GO:0071542 (dopaminergic neuron differentiation)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0071773 (cellular response to BMP stimulus)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090175 (regulation of establishment of planar polarity)
GO:0090179 (planar cell polarity pathway involved in neural tube closure)
GO:0090244 (Wnt signaling pathway involved in somitogenesis)
GO:0090246 (convergent extension involved in somitogenesis)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1902043 (positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1904956 (regulation of midbrain dopaminergic neuron differentiation)
GO:2000041 (negative regulation of planar cell polarity pathway involved in axis elongation)
GO:2000052 (positive regulation of non-canonical Wnt signaling pathway)
GO:2000054 (negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)
GO:2000080 (negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)
GO:2000270 (negative regulation of fibroblast apoptotic process)
GO:2000271 (positive regulation of fibroblast apoptotic process)
GO:2001238 (positive regulation of extrinsic apoptotic signaling pathway)
Wikipedia Secreted_frizzled-related_protein_1

Target Cross References - Protein

canSAR Q8N474
Human Protein Atlas ENSG00000104332
IntAct Q8N474
Open Targets ENSG00000104332
PharmGKB PA35692
Reactome R-HSA-201681 (TCF dependent signaling in response to WNT.)
R-HSA-3772470 (Negative regulation of TCF-dependent signaling by WNT ligand antagonists.)
UniProt O00546 O14779 Q8N474

Target Cross References - Domain

InterPro IPR001134 (Netrin_domain.)
IPR008993 (TIMP-like_OB-fold.)
IPR015526 (Frizzled/SFRP.)
IPR018933 (Netrin_module_non-TIMP.)
IPR020067 (Frizzled_dom.)
IPR026559 (SFRP1.)
IPR036790 (Frizzled_dom_sf.)
Pfam PF01392 (Fz)
PF01759 (NTR)