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Target Report Card

Target Name and Classification

Target ID CHEMBL5516
Preferred Name Monoacylglycerol lipase ABHD12
Synonyms 2-arachidonoylglycerol hydrolase | ABHD12 | Abhydrolase domain-containing protein 12 | Monoacylglycerol lipase ABHD12 | Synonyms=C20orf22
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Monoacylglycerol lipase ABHD12 SINGLE PROTEIN Q8N2K0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100997
Ensembl ENSG00000100997
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0032281 (AMPA glutamate receptor complex)
GO:0032839 (dendrite cytoplasm)
GO Molecular Function GO:0004622 (lysophospholipase activity)
GO:0008474 (palmitoyl-(protein) hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0047372 (acylglycerol lipase activity)
GO Biological Process GO:0002084 (protein depalmitoylation)
GO:0006660 (phosphatidylserine catabolic process)
GO:0007628 (adult walking behavior)
GO:0010996 (response to auditory stimulus)
GO:0046464 (acylglycerol catabolic process)
GO:0046475 (glycerophospholipid catabolic process)
GO:0052651 (monoacylglycerol catabolic process)

Target Cross References - Protein

canSAR Q8N2K0
CGD Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract
Human Protein Atlas ENSG00000100997
IntAct Q8N2K0
Open Targets ENSG00000100997
PharmGKB PA25738
Reactome R-HSA-426048 (Arachidonate production from DAG.)
UniProt A6NED4 A6NJ90 A8K450 B4DE71 Q5T710 Q5T711 Q8N2K0 Q96CR1 Q9BX05 Q9NPX7 Q9UFV6

Target Cross References - Domain

InterPro IPR022742 (Hydrolase_4.)
IPR026605 (ABHD12.)
IPR029058 (AB_hydrolase.)
Pfam PF12146 (Hydrolase_4)