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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5491
Preferred Name Serine/threonine-protein kinase WEE1
Synonyms WEE1 | WEE1hu | Wee1-like protein kinase | Wee1A kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase wee family

Target Components

Component Description Relationship Accession
Wee1-like protein kinase SINGLE PROTEIN P30291

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1976040 AZD-1775 Serine/threonine-protein kinase WEE1 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166483
Ensembl ENSG00000166483
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000226 (microtubule cytoskeleton organization)
GO:0000278 (mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030010 (establishment of cell polarity)
GO:0048812 (neuron projection morphogenesis)
GO:0051301 (cell division)
GO:0051726 (regulation of cell cycle)
Wikipedia Wee1-like_protein_kinase

Target Cross References - Protein

canSAR P30291
Human Protein Atlas ENSG00000166483
IntAct P30291
Guide to Pharmacology 2278
Open Targets ENSG00000166483
PharmGKB PA366
Pharos P30291 (Tchem)
Reactome R-HSA-156711 (Polo-like kinase mediated events.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69273 (Cyclin A/B1/B2 associated events during G2/M transition.)
R-HSA-69478 (G2/M DNA replication checkpoint.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-75035 (Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt B3KVE1 D3DQV0 P30291

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017164 (Wee1-like_protein_kinase.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0 5V5Y 5VC3 5VC4 5VC5 5VC6 5VD2
CREDO 1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0 5V5Y 5VC3 5VC4 5VC5 5VC6 5VD2