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Target Report Card

Target Name and Classification

Target ID CHEMBL5485
Preferred Name D-amino-acid oxidase
Synonyms D-amino-acid oxidase | DAAO | DAMOX | DAMOX | DAO | DAO
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
D-amino-acid oxidase SINGLE PROTEIN P14920

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110887
Ensembl ENSG00000110887
GO Cellular Component GO:0005741 (mitochondrial outer membrane)
GO:0005777 (peroxisome)
GO:0005778 (peroxisomal membrane)
GO:0005782 (peroxisomal matrix)
GO:0005829 (cytosol)
GO Molecular Function GO:0003884 (D-amino-acid oxidase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0046983 (protein dimerization activity)
GO:0048037 (cofactor binding)
GO:0071949 (FAD binding)
GO Biological Process GO:0006562 (proline catabolic process)
GO:0034641 (cellular nitrogen compound metabolic process)
GO:0036088 (D-serine catabolic process)
GO:0042416 (dopamine biosynthetic process)
GO:0046416 (D-amino acid metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0055130 (D-alanine catabolic process)
GO:0070178 (D-serine metabolic process)

Target Cross References - Protein

canSAR P14920
Human Protein Atlas ENSG00000110887
IntAct P14920
Open Targets ENSG00000110887
PharmGKB PA27139
Reactome R-HSA-389661 (Glyoxylate metabolism and glycine degradation.)
UniProt B2R7I5 P14920 Q16758 Q8N6R2

Target Cross References - Domain

InterPro IPR006076 (FAD-dep_OxRdtase.)
IPR006181 (D-amino_acid_oxidase_CS.)
IPR023209 (DAO.)
Pfam PF01266 (DAO)

Target Cross References - Structure

PDBe 2DU8 2E48 2E49 2E4A 2E82 3CUK 3G3E 3W4I 3W4J 3W4K 3ZNN 3ZNO 3ZNP 3ZNQ 4QFC 4QFD
CREDO 2DU8 2E48 2E49 2E4A 2E82 3CUK 3G3E 3W4I 3W4J 3W4K 3ZNN 3ZNO 3ZNP 3ZNQ 4QFC 4QFD