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Target Report Card

Target Name and Classification

Target ID CHEMBL5483
Preferred Name Insulin receptor-related protein
Synonyms INSRR | IR-related receptor | IRR | IRR | Insulin receptor-related protein alpha chain | Insulin receptor-related protein beta chain | Insulin receptor-related protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase insr family

Target Components

Component Description Relationship Accession
Insulin receptor-related protein SINGLE PROTEIN P14616

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000027644
Ensembl ENSG00000027644
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0043560 (insulin receptor substrate binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030238 (male sex determination)
GO:0031532 (actin cytoskeleton reorganization)
GO:0046777 (protein autophosphorylation)
GO:0071469 (cellular response to alkaline pH)
Wikipedia INSRR

Target Cross References - Protein

canSAR P14616
Human Protein Atlas ENSG00000027644
IntAct P14616
Guide to Pharmacology 1802
Open Targets ENSG00000027644
PharmGKB PA29899
Pharos P14616 (Tchem)
UniProt O60724 P14616 Q5VZS3

Target Cross References - Domain

InterPro IPR000494 (Rcpt_L-dom.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR003961 (FN3_dom.)
IPR006211 (Furin-like_Cys-rich_dom.)
IPR006212 (Furin_repeat.)
IPR008266 (Tyr_kinase_AS.)
IPR009030 (Growth_fac_rcpt_cys_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR013783 (Ig-like_fold.)
IPR016246 (Tyr_kinase_insulin-like_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR028792 (INSRR.)
IPR036116 (FN3_sf.)
IPR036941 (Rcpt_L-dom_sf.)
Pfam PF00757 (Furin-like)
PF01030 (Recep_L_domain)
PF07714 (Pkinase_Tyr)