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Target Report Card

Target Name and Classification

Target ID CHEMBL5469
Preferred Name Protein tyrosine kinase 2 beta
Synonyms CADTK | CAK-beta | CAKB | Calcium-dependent tyrosine kinase | Calcium-regulated non-receptor proline-rich tyrosine kinase | Cell adhesion kinase beta | FADK 2 | FAK2 | Focal adhesion kinase 2 | PTK2B | PYK2 | Proline-rich tyrosine kinase 2 | Protein-tyrosine kinase 2-beta | RAFTK | RAFTK | Related adhesion focal tyrosine kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fak family

Target Components

Component Description Relationship Accession
Protein-tyrosine kinase 2-beta SINGLE PROTEIN Q14289

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3137331 DEFACTINIB Protein tyrosine kinase 2 beta inhibitor 2 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000120899
Ensembl ENSG00000120899
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0005938 (cell cortex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0044297 (cell body)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0097440 (apical dendrite)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0043423 (3-phosphoinositide-dependent protein kinase binding)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000302 (response to reactive oxygen species)
GO:0001525 (angiogenesis)
GO:0001556 (oocyte maturation)
GO:0001666 (response to hypoxia)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0002040 (sprouting angiogenesis)
GO:0002250 (adaptive immune response)
GO:0002315 (marginal zone B cell differentiation)
GO:0002376 (immune system process)
GO:0002688 (regulation of leukocyte chemotaxis)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006968 (cellular defense response)
GO:0006970 (response to osmotic stress)
GO:0007015 (actin filament organization)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007172 (signal complex assembly)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0009612 (response to mechanical stimulus)
GO:0009725 (response to hormone)
GO:0009749 (response to glucose)
GO:0010226 (response to lithium ion)
GO:0010243 (response to organonitrogen compound)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010656 (negative regulation of muscle cell apoptotic process)
GO:0010752 (regulation of cGMP-mediated signaling)
GO:0010758 (regulation of macrophage chemotaxis)
GO:0010976 (positive regulation of neuron projection development)
GO:0014009 (glial cell proliferation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030155 (regulation of cell adhesion)
GO:0030279 (negative regulation of ossification)
GO:0030307 (positive regulation of cell growth)
GO:0030334 (regulation of cell migration)
GO:0030335 (positive regulation of cell migration)
GO:0030500 (regulation of bone mineralization)
GO:0030502 (negative regulation of bone mineralization)
GO:0030826 (regulation of cGMP biosynthetic process)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031175 (neuron projection development)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032960 (regulation of inositol trisphosphate biosynthetic process)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035902 (response to immobilization stress)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038110 (interleukin-2-mediated signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042976 (activation of Janus kinase activity)
GO:0043066 (negative regulation of apoptotic process)
GO:0043149 (stress fiber assembly)
GO:0043267 (negative regulation of potassium ion transport)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043534 (blood vessel endothelial cell migration)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045087 (innate immune response)
GO:0045428 (regulation of nitric oxide biosynthetic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045453 (bone resorption)
GO:0045471 (response to ethanol)
GO:0045638 (negative regulation of myeloid cell differentiation)
GO:0045727 (positive regulation of translation)
GO:0045765 (regulation of angiogenesis)
GO:0045766 (positive regulation of angiogenesis)
GO:0045860 (positive regulation of protein kinase activity)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048041 (focal adhesion assembly)
GO:0048167 (regulation of synaptic plasticity)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050848 (regulation of calcium-mediated signaling)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051279 (regulation of release of sequestered calcium ion into cytosol)
GO:0051591 (response to cAMP)
GO:0051592 (response to calcium ion)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060291 (long-term synaptic potentiation)
GO:0060292 (long term synaptic depression)
GO:0065003 (protein-containing complex assembly)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071300 (cellular response to retinoic acid)
GO:0071498 (cellular response to fluid shear stress)
GO:0090630 (activation of GTPase activity)
GO:2000058 (regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:2000060 (positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:2000114 (regulation of establishment of cell polarity)
GO:2000249 (regulation of actin cytoskeleton reorganization)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2000463 (positive regulation of excitatory postsynaptic potential)
GO:2000538 (positive regulation of B cell chemotaxis)
GO:2000573 (positive regulation of DNA biosynthetic process)
Wikipedia PTK2B

Target Cross References - Protein

canSAR Q14289
Human Protein Atlas ENSG00000120899
IntAct Q14289
Guide to Pharmacology 2181
Open Targets ENSG00000120899
PharmGKB PA33956
Pharos Q14289 (Tchem)
Reactome R-HSA-391160 (Signal regulatory protein family interactions.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-9020558 (Interleukin-2 signaling.)
UniProt D3DST0 Q13475 Q14289 Q14290 Q16709 Q6PID4

Target Cross References - Domain

InterPro IPR000299 (FERM_domain.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR005189 (Focal_adhesion_kin_target_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011993 (PH-like_dom_sf.)
IPR014352 (FERM/acyl-CoA-bd_prot_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR019748 (FERM_central.)
IPR019749 (Band_41_domain.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR029071 (Ubiquitin-like_domsf.)
IPR030610 (PTK2B.)
IPR035963 (FERM_2.)
IPR036137 (Focal_adhe_kin_target_dom_sf.)
Pfam PF00373 (FERM_M)
PF03623 (Focal_AT)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32 4XEF 4XEK 4XEV 5TO8 5TOB