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Target Report Card

Target Name and Classification

Target ID CHEMBL5467
Target Type SINGLE PROTEIN
Preferred Name Bone morphogenetic protein receptor type-2
Synonyms BMP type II receptor | BMP type-2 receptor | BMPR-2 | BMPR-II | BMPR2 | Bone morphogenetic protein receptor type II | Bone morphogenetic protein receptor type-2 | PPH1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 2 subfamily

Target Components

Component Description Relationship Accession
Bone morphogenetic protein receptor type-2 SINGLE PROTEIN Q13873

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204217
Ensembl ENSG00000204217
GO Cellular Component GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0005913 (cell-cell adherens junction)
GO:0009925 (basal plasma membrane)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0044214 (spanning component of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016362 (activin receptor activity, type II)
GO:0016740 (transferase activity)
GO:0019838 (growth factor binding)
GO:0036122 (BMP binding)
GO:0046872 (metal ion binding)
GO:0098821 (BMP receptor activity)
GO Biological Process GO:0001707 (mesoderm formation)
GO:0001893 (maternal placenta development)
GO:0001935 (endothelial cell proliferation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0001946 (lymphangiogenesis)
GO:0001974 (blood vessel remodeling)
GO:0002063 (chondrocyte development)
GO:0003085 (negative regulation of systemic arterial blood pressure)
GO:0003148 (outflow tract septum morphogenesis)
GO:0003151 (outflow tract morphogenesis)
GO:0003181 (atrioventricular valve morphogenesis)
GO:0003183 (mitral valve morphogenesis)
GO:0003186 (tricuspid valve morphogenesis)
GO:0003197 (endocardial cushion development)
GO:0003252 (negative regulation of cell proliferation involved in heart valve morphogenesis)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007420 (brain development)
GO:0009267 (cellular response to starvation)
GO:0009952 (anterior/posterior pattern specification)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0014916 (regulation of lung blood pressure)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030166 (proteoglycan biosynthetic process)
GO:0030308 (negative regulation of cell growth)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0030513 (positive regulation of BMP signaling pathway)
GO:0032924 (activin receptor signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045778 (positive regulation of ossification)
GO:0045906 (negative regulation of vasoconstriction)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048286 (lung alveolus development)
GO:0048738 (cardiac muscle tissue development)
GO:0048842 (positive regulation of axon extension involved in axon guidance)
GO:0060041 (retina development in camera-type eye)
GO:0060173 (limb development)
GO:0060350 (endochondral bone morphogenesis)
GO:0060412 (ventricular septum morphogenesis)
GO:0060413 (atrial septum morphogenesis)
GO:0060836 (lymphatic endothelial cell differentiation)
GO:0060840 (artery development)
GO:0060841 (venous blood vessel development)
GO:0061036 (positive regulation of cartilage development)
GO:0061298 (retina vasculature development in camera-type eye)
GO:0061626 (pharyngeal arch artery morphogenesis)
GO:0071773 (cellular response to BMP stimulus)
GO:0072577 (endothelial cell apoptotic process)
GO:1902731 (negative regulation of chondrocyte proliferation)
GO:1905314 (semi-lunar valve development)
GO:2000279 (negative regulation of DNA biosynthetic process)

Target Cross References - Protein

canSAR Q13873
CGD Pulmonary hypertension, primary; Pulmonary venoocclusive disease
Human Protein Atlas ENSG00000204217
IntAct Q13873
Guide to Pharmacology 1794
Open Targets ENSG00000204217
PharmGKB PA25388
Pharos Q13873 (Tchem)
Reactome R-HSA-201451 (Signaling by BMP.)
UniProt Q13161 Q13873 Q16569 Q4ZG08 Q53SA5 Q585T8

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000472 (Activin_recp.)
IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR015770 (BMPR2.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF01064 (Activin_recp)

Target Cross References - Structure

PDBe 2HLQ 3G2F
CREDO 2HLQ 3G2F
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