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Target Report Card

Target Name and Classification

Target ID CHEMBL5466
Preferred Name Activin receptor type-2B
Synonyms ACTR-IIB | ACVR2B | Activin receptor type IIB | Activin receptor type-2B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 2 subfamily

Target Components

Component Description Relationship Accession
Activin receptor type-2B SINGLE PROTEIN Q13705

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3137353 BIMAGRUMAB Activin receptor type-2B antagonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000114739
Ensembl ENSG00000114739
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043234 (protein complex)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016362 (activin receptor activity, type II)
GO:0016740 (transferase activity)
GO:0019838 (growth factor binding)
GO:0034711 (inhibin binding)
GO:0046872 (metal ion binding)
GO:0048185 (activin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001501 (skeletal system development)
GO:0001702 (gastrulation with mouth forming second)
GO:0001822 (kidney development)
GO:0001946 (lymphangiogenesis)
GO:0001974 (blood vessel remodeling)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007368 (determination of left/right symmetry)
GO:0007389 (pattern specification process)
GO:0007498 (mesoderm development)
GO:0007507 (heart development)
GO:0009749 (response to glucose)
GO:0009791 (post-embryonic development)
GO:0009952 (anterior/posterior pattern specification)
GO:0009966 (regulation of signal transduction)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030073 (insulin secretion)
GO:0030324 (lung development)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0031016 (pancreas development)
GO:0032147 (activation of protein kinase activity)
GO:0032924 (activin receptor signaling pathway)
GO:0032927 (positive regulation of activin receptor signaling pathway)
GO:0035265 (organ growth)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0048617 (embryonic foregut morphogenesis)
GO:0048705 (skeletal system morphogenesis)
GO:0060021 (palate development)
GO:0060836 (lymphatic endothelial cell differentiation)
GO:0060840 (artery development)
GO:0060841 (venous blood vessel development)
GO:0061298 (retina vasculature development in camera-type eye)
Wikipedia ACVR2B

Target Cross References - Protein

canSAR Q13705
CGD Heterotaxy, visceral, 4, autosomal
Human Protein Atlas ENSG00000114739
IntAct Q13705
Guide to Pharmacology 1792
Open Targets ENSG00000114739
PharmGKB PA24495
Pharos Q13705 (Tchem)
Reactome R-HSA-1181150 (Signaling by NODAL.)
R-HSA-1433617 (Regulation of signaling by NODAL.)
R-HSA-1502540 (Signaling by Activin.)
R-HSA-201451 (Signaling by BMP.)
UniProt Q13705 Q4VAV0

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000472 (Activin_recp.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF01064 (Activin_recp)

Target Cross References - Structure