ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5464
Preferred Name Receptor-interacting serine/threonine-protein kinase 1
Synonyms Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Serine/threonine-protein kinase RIP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase ripk family

Target Components

Component Description Relationship Accession
Receptor-interacting serine/threonine-protein kinase 1 SINGLE PROTEIN Q13546

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137275
Ensembl ENSG00000137275
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0010008 (endosome membrane)
GO:0031264 (death-inducing signaling complex)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005123 (death receptor binding)
GO:0005524 (ATP binding)
GO:0070513 (death domain binding)
GO Biological Process GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006919 (activation of caspase activity)
GO:0007257 (activation of JUN kinase activity)
GO:0008063 (Toll signaling pathway)
GO:0008624 (induction of apoptosis by extracellular signals)
GO:0008633 (activation of pro-apoptotic gene products)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0045087 (innate immune response)
GO:0045768 (positive regulation of anti-apoptosis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046777 (protein autophosphorylation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0060555 (induction of necroptosis by extracellular signals)
GO:0070926 (regulation of ATP:ADP antiporter activity)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia RIPK1

Target Cross References - Protein

canSAR Q13546
Human Protein Atlas ENSG00000137275
IntAct Q13546
Guide to Pharmacology 2189 (receptor (TNFRSF)-interacting serine-threonine kinase 1)
PharmGKB PA34394
Reactome REACT_578 (Apoptosis.)
REACT_6900 (Signaling in Immune system.)
UniProt A0AV89 B2RAG1 B4E3F9 Q13180 Q13546 Q59H33

Target Cross References - Domain

InterPro IPR000488 (Death.)
IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011029 (DEATH-like.)
Pfam PF00531 (Death)
PF07714 (Pkinase_Tyr)