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Target Report Card

Target Name and Classification

Target ID CHEMBL5462
Preferred Name Baculoviral IAP repeat-containing protein 2
Synonyms API1 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | C-IAP1 | Cellular inhibitor of apoptosis 1 | IAP homolog B | Inhibitor of apoptosis protein 2 | MIHB | RING finger protein 48 | RING-type E3 ubiquitin transferase BIRC2 | RNF48 | TNFR2-TRAF-signaling complex protein 2 | hIAP-2 | hIAP2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Baculoviral IAP repeat-containing protein 2 SINGLE PROTEIN Q13490

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221342 Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110330
Ensembl ENSG00000110330
GO Cellular Component GO:0001741 (XY body)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005876 (spindle microtubule)
GO:0009898 (cytoplasmic side of plasma membrane)
GO:0035631 (CD40 receptor complex)
GO:0043234 (protein complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0004842 (ubiquitin-protein transferase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016740 (transferase activity)
GO:0016874 (ligase activity)
GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process)
GO:0046872 (metal ion binding)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0001666 (response to hypoxia)
GO:0001890 (placenta development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006915 (apoptotic process)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0010243 (response to organonitrogen compound)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0010939 (regulation of necrotic cell death)
GO:0014070 (response to organic cyclic compound)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034121 (regulation of toll-like receptor signaling pathway)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0039535 (regulation of RIG-I signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0045088 (regulation of innate immune response)
GO:0045471 (response to ethanol)
GO:0045595 (regulation of cell differentiation)
GO:0050727 (regulation of inflammatory response)
GO:0051291 (protein heterooligomerization)
GO:0051591 (response to cAMP)
GO:0051726 (regulation of cell cycle)
GO:0060544 (regulation of necroptotic process)
GO:0060546 (negative regulation of necroptotic process)
GO:0070266 (necroptotic process)
GO:0070424 (regulation of nucleotide-binding oligomerization domain containing signaling pathway)
GO:0090307 (mitotic spindle assembly)
GO:1902443 (negative regulation of ripoptosome assembly involved in necroptotic process)
GO:1902523 (positive regulation of protein K63-linked ubiquitination)
GO:1902524 (positive regulation of protein K48-linked ubiquitination)
GO:1902527 (positive regulation of protein monoubiquitination)
GO:1990001 (inhibition of cysteine-type endopeptidase activity involved in apoptotic process)
GO:2000116 (regulation of cysteine-type endopeptidase activity)
GO:2000377 (regulation of reactive oxygen species metabolic process)
Wikipedia BIRC2

Target Cross References - Protein

canSAR Q13490
Human Protein Atlas ENSG00000110330
IntAct Q13490
Guide to Pharmacology 2791
Open Targets ENSG00000110330
PharmGKB PA25359
Reactome R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-5213460 (RIPK1-mediated regulated necrosis.)
R-HSA-5357905 (Regulation of TNFR1 signaling.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-5675482 (Regulation of necroptotic cell death.)
R-HSA-5676594 (TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-937041 (IKK complex recruitment mediated by RIP1.)
UniProt B4E026 Q13490 Q16516 Q4TTG0

Target Cross References - Domain

InterPro IPR001315 (CARD.)
IPR001370 (BIR_rpt.)
IPR001841 (Znf_RING.)
IPR011029 (DEATH-like_dom.)
IPR028795 (C-IAP1.)
Pfam PF00619 (CARD)
PF00653 (BIR)

Target Cross References - Structure

PDBe 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7
CREDO 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7