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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5441
Target Type SINGLE PROTEIN
Preferred Name Dihydrofolate reductase
Synonyms Dihydrofolate reductase | dfrA17
Organism Escherichia coli
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Dihydrofolate reductase SINGLE PROTEIN B0BL08

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0004146 (dihydrofolate reductase activity)
GO:0050661 (NADP binding)
GO Biological Process GO:0006545 (glycine biosynthetic process)
GO:0009165 (nucleotide biosynthetic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR B0BL08
UniProt B0BL08

Target Cross References - Domain

InterPro IPR001796 (DHFR_dom.)
IPR012259 (DHFR.)
IPR017925 (DHFR_CS.)
IPR024072 (DHFR-like_dom.)
Pfam PF00186 (DHFR_1)
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