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Target Report Card

Target Name and Classification

Target ID CHEMBL5435
Preferred Name Serine/threonine-protein kinase ULK2
Synonyms KIAA0623 | Serine/threonine-protein kinase ULK2 | ULK2 | Unc-51-like kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase ulk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase ULK2 SINGLE PROTEIN Q8IYT8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000083290
Ensembl ENSG00000083290
GO Cellular Component GO:0016020 (membrane)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0034045 (pre-autophagosomal structure membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006914 (autophagy)
GO:0007165 (signal transduction)
GO:0007399 (nervous system development)
GO:0007409 (axonogenesis)
GO:0016310 (phosphorylation)
GO:0042594 (response to starvation)
GO:0046777 (protein autophosphorylation)
GO:0048671 (negative regulation of collateral sprouting)
GO:0048675 (axon extension)
GO:0075044 (autophagy of host cells involved in interaction with symbiont)

Target Cross References - Protein

Human Protein Atlas ENSG00000083290
IntAct Q8IYT8
Guide to Pharmacology 2272
Open Targets ENSG00000083290
PharmGKB PA37780
Pharos Q8IYT8 (Tchem)
UniProt A8MY69 O75119 Q8IYT8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016237 (Ser/Thr_kin_STPK_Ulk-1/2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR022708 (Ser/Thr_kinase_C.)
Pfam PF00069 (Pkinase)
PF12063 (DUF3543)