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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5432
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase kinase 3
Synonyms GLK | Germinal center kinase-related protein kinase | MAP4K3 | MAPK/ERK kinase kinase kinase 3 | MEK kinase kinase 3 | MEKKK 3 | Mitogen-activated protein kinase kinase kinase kinase 3 | RAB8IPL1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase khs subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase kinase 3 SINGLE PROTEIN Q8IVH8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000011566
Ensembl ENSG00000011566
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008349 (MAP kinase kinase kinase kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000185 (activation of MAPKKK activity)
GO:0006468 (protein phosphorylation)
GO:0007254 (JNK cascade)
GO:0007346 (regulation of mitotic cell cycle)
GO:0009411 (response to UV)
GO:0016310 (phosphorylation)
GO:0034612 (response to tumor necrosis factor)
GO:0035556 (intracellular signal transduction)
GO:0042981 (regulation of apoptotic process)

Target Cross References - Protein

canSAR Q8IVH8
Human Protein Atlas ENSG00000011566
IntAct Q8IVH8
Guide to Pharmacology 2087
Open Targets ENSG00000011566
PharmGKB PA30611
Pharos Q8IVH8 (Tchem)
UniProt Q6IQ39 Q8IVH7 Q8IVH8 Q9UDM5 Q9Y6R5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001180 (CNH_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR021160 (MAPKKKK.)
Pfam PF00069 (Pkinase)
PF00780 (CNH)

Target Cross References - Structure

PDBe 5J5T
CREDO 5J5T
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