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Target Report Card

Target Name and Classification

Target ID CHEMBL5427
Preferred Name Homeodomain-interacting protein kinase 1
Synonyms HIPK1 | Homeodomain-interacting protein kinase 1 | KIAA0630 | MYAK | NBAK2 | Nuclear body-associated kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase dyrk family > cmgc protein kinase hipk subfamily

Target Components

Component Description Relationship Accession
Homeodomain-interacting protein kinase 1 SINGLE PROTEIN Q86Z02

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163349
Ensembl ENSG00000163349
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0016605 (PML body)
GO:0016607 (nuclear speck)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001654 (eye development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0007224 (smoothened signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0009952 (anterior/posterior pattern specification)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0010842 (retina layer formation)
GO:0016310 (phosphorylation)
GO:0030182 (neuron differentiation)
GO:0034333 (adherens junction assembly)
GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:0045766 (positive regulation of angiogenesis)
GO:0048596 (embryonic camera-type eye morphogenesis)
GO:0060059 (embryonic retina morphogenesis in camera-type eye)
GO:0060216 (definitive hemopoiesis)
GO:0060235 (lens induction in camera-type eye)
GO:0061072 (iris morphogenesis)
GO:0072577 (endothelial cell apoptotic process)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia HIPK1

Target Cross References - Protein

canSAR Q86Z02
Human Protein Atlas ENSG00000163349
IntAct Q86Z02
Guide to Pharmacology 2033
Open Targets ENSG00000163349
PharmGKB PA134897980
Pharos Q86Z02 (Tbio)
Reactome R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-5578768 (Physiological factors.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt A6NJ34 O75125 Q5SQL2 Q5SQL4 Q5SQL5 Q86Z02 Q8IYD7 Q8NDN5 Q8NEB6 Q8TBZ1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)