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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5416
Target Type SINGLE PROTEIN
Preferred Name PITSLRE serine/threonine-protein kinase CDC2L2
Synonyms CDC2L2 | CDC2L3 | CDK11A | Cell division cycle 2-like protein kinase 2 | Cell division protein kinase 11A | Cyclin-dependent kinase 11A | Galactosyltransferase-associated protein kinase p58/GTA | PITSLRE serine/threonine-protein kinase CDC2L2 | PITSLREB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase pitslre subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 11A SINGLE PROTEIN Q9UQ88

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000008128
Ensembl ENSG00000008128
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000278 (mitotic cell cycle)
GO:0001558 (regulation of cell growth)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0050684 (regulation of mRNA processing)
Wikipedia CDC2L2

Target Cross References - Protein

Human Protein Atlas ENSG00000008128
IntAct Q9UQ88
Guide to Pharmacology 1963
Open Targets ENSG00000008128
PharmGKB PA26263
Pharos Q9UQ88 (Tbio)
Reactome R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
UniProt O95227 O95228 O96012 Q12821 Q12853 Q12854 Q2TAJ0 Q5QPR0 Q5QPR1 Q5QPR2 Q9UBC4 Q9UBI3 Q9UEI1 Q9UEI2 Q9UP53 Q9UP54 Q9UP55 Q9UP56 Q9UQ86 Q9UQ87 Q9UQ88 Q9UQ89

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
Pfam PF00069 (Pkinase)
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