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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5408
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase TBK1
Synonyms NAK | NF-kappa-B-activating kinase | Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 | TBK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase ikk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase TBK1 SINGLE PROTEIN Q9UHD2

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038486 IKK epsilon/TBK1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000183735
Ensembl ENSG00000183735
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0010008 (endosome membrane)
GO:0016235 (aggresome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003676 (nucleic acid binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0002218 (activation of innate immune response)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0009615 (response to virus)
GO:0010629 (negative regulation of gene expression)
GO:0016032 (viral process)
GO:0016239 (positive regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0032479 (regulation of type I interferon production)
GO:0032480 (negative regulation of type I interferon production)
GO:0032481 (positive regulation of type I interferon production)
GO:0032606 (type I interferon production)
GO:0032727 (positive regulation of interferon-alpha production)
GO:0032728 (positive regulation of interferon-beta production)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0044565 (dendritic cell proliferation)
GO:0045087 (innate immune response)
GO:0045359 (positive regulation of interferon-beta biosynthetic process)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051607 (defense response to virus)
GO:0071345 (cellular response to cytokine stimulus)
GO:1901214 (regulation of neuron death)
GO:1904417 (positive regulation of xenophagy)
Wikipedia TANK-binding_kinase_1

Target Cross References - Protein

canSAR Q9UHD2
Human Protein Atlas ENSG00000183735
IntAct Q9UHD2
Guide to Pharmacology 2237
Open Targets ENSG00000183735
PharmGKB PA36348
Pharos Q9UHD2 (Tchem)
Reactome R-HSA-1606341 (IRF3 mediated activation of type 1 IFN.)
R-HSA-3134975 (Regulation of innate immune responses to cytosolic DNA.)
R-HSA-3249367 (STAT6-mediated induction of chemokines.)
R-HSA-3270619 (IRF3-mediated induction of type I IFN.)
R-HSA-9008059 (Interleukin-37 signaling.)
R-HSA-9013973 (TICAM1-dependent activation of IRF3/IRF7.)
R-HSA-918233 (TRAF3-dependent IRF activation pathway.)
R-HSA-933541 (TRAF6 mediated IRF7 activation.)
R-HSA-936440 (Negative regulators of DDX58/IFIH1 signaling.)
R-HSA-936964 (Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.)
UniProt A8K4S4 Q8IYV3 Q9NUJ5 Q9UHD2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6
CREDO 4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6
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