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Target Report Card

Target Name and Classification

Target ID CHEMBL5404
Preferred Name Serine/threonine-protein kinase tousled-like 2
Synonyms HsHPK | PKU-alpha | Serine/threonine-protein kinase tousled-like 2 | TLK2 | Tousled-like kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase tlk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase tousled-like 2 SINGLE PROTEIN Q86UE8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000146872
Ensembl ENSG00000146872
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0005882 (intermediate filament)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001672 (regulation of chromatin assembly or disassembly)
GO:0006325 (chromatin organization)
GO:0006468 (protein phosphorylation)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0010507 (negative regulation of autophagy)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032435 (negative regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0035556 (intracellular signal transduction)
GO:0071480 (cellular response to gamma radiation)
Wikipedia TLK2

Target Cross References - Protein

canSAR Q86UE8
Human Protein Atlas ENSG00000146872
IntAct Q86UE8
Guide to Pharmacology 2243
Open Targets ENSG00000146872
PharmGKB PA36544
Pharos Q86UE8 (Tchem)
UniProt D3DU07 Q86UE8 Q9UKI7 Q9Y4F7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR027086 (TLK2.)
Pfam PF00069 (Pkinase)