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Target Report Card

Target Name and Classification

Target ID CHEMBL5400
Preferred Name Aryl hydrocarbon receptor
Synonyms Ah receptor | AhR | Ahr | Aryl hydrocarbon receptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Aryl hydrocarbon receptor SINGLE PROTEIN P41738

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0034751 (aryl hydrocarbon receptor complex)
GO:0034753 (nuclear aryl hydrocarbon receptor complex)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004874 (aryl hydrocarbon receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0046983 (protein dimerization activity)
GO:0070888 (E-box binding)
GO Biological Process GO:0001541 (ovarian follicle development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006915 (apoptotic process)
GO:0006950 (response to stress)
GO:0007049 (cell cycle)
GO:0009410 (response to xenobiotic stimulus)
GO:0014070 (response to organic cyclic compound)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032355 (response to estradiol)
GO:0032922 (circadian regulation of gene expression)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0071385 (cellular response to glucocorticoid stimulus)

Target Cross References - Protein

canSAR P41738
IntAct P41738
UniProt O88930 O89105 P41738

Target Cross References - Domain

InterPro IPR000014 (PAS.)
IPR001610 (PAC.)
IPR011598 (bHLH_dom.)
IPR013655 (PAS_fold_3.)
IPR013767 (PAS_fold.)
IPR033348 (AHR.)
Pfam PF00010 (HLH)
PF00989 (PAS)
PF08447 (PAS_3)