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Target Report Card

Target Name and Classification

Target ID CHEMBL5377
Preferred Name Serotonin 2a (5-HT2a) receptor
Synonyms 5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | Htr2 | Htr2a | Serotonin receptor 2A
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 2A SINGLE PROTEIN P35363

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2109245 Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor SELECTIVITY GROUP
CHEMBL2096671 Serotonin 2 (5-HT2) receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0043198 (dendritic shaft)
GO:0070852 (cell body fiber)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0008144 (drug binding)
GO:0030594 (neurotransmitter receptor activity)
GO:0044877 (macromolecular complex binding)
GO:0051378 (serotonin binding)
GO:0071886 (1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007208 (phospholipase C-activating serotonin receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007568 (aging)
GO:0007610 (behavior)
GO:0007613 (memory)
GO:0008219 (cell death)
GO:0008284 (positive regulation of cell proliferation)
GO:0010513 (positive regulation of phosphatidylinositol biosynthetic process)
GO:0014059 (regulation of dopamine secretion)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0014824 (artery smooth muscle contraction)
GO:0014832 (urinary bladder smooth muscle contraction)
GO:0019233 (sensory perception of pain)
GO:0030431 (sleep)
GO:0033674 (positive regulation of kinase activity)
GO:0042493 (response to drug)
GO:0043267 (negative regulation of potassium ion transport)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0044380 (protein localization to cytoskeleton)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045821 (positive regulation of glycolytic process)
GO:0045907 (positive regulation of vasoconstriction)
GO:0048148 (behavioral response to cocaine)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)

Target Cross References - Protein

canSAR P35363
IntAct P35363
MICAD NBK23366 (5-HT2A serotonin receptors)
NBK53688 (5-HT2A serotonin receptor)
Reactome R-MMU-390666 (Serotonin receptors.)
R-MMU-416476 (G alpha (q) signalling events.)
UniProt P35363

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000455 (5HT2A_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)